Low DHEA sulfate on labs

gdw5078

New Member
On TRT and majority of blood work in optimal ranges except DHEA-S. Not sure if I should supplement with DHEA or if it is unnecessary since I am on TRT. I have been taking 7 Keto dhea on dr advice but that clearly doesn’t affect my dhea-s levels.
 
I agree with Vince Carter that DHEA will convert some testosterone into estrogen. Because I don't need an AI, I supplement with 25 mg of DHEA and 10 mg of Pregnenolone to keep my levels in the good range. I take it before bed and it does help me sleep better.

DHEA - Sulfate 347.3 range 48.9 - 344.2
 
If you have higher E2 then you probably don't want to supplement with DHEA. Like Vince, I supplement with 25 mg of DHEA but I supplement a little higher with my Pregnenolone, 25 mg. I take at night prior to bed. I sleep really good. My DHEA-s is 322.8 and with the supplementation my E2 sits at 35.3 which I feel good at and take no AI.

The reason I take 25 mg of Pregnenolone is that when tested it registered <10 and I've read that the optimal range for a man is at 150 to 180. It has now come up to 41. It is also considered the Grandmother of all hormones and I am trying to back fill the pathway.
 
I don't think it's necessary and can easily aromatase for men.
Thanks. I already take 1.5 mg of anastrozole a week and DIM to keep e2 in check so Thst was one of my concerns. Dhea was at 140 so on low end of range and didn’t know if I should be concerned. Test was 804
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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