Lipo-C - Who's using / what doses?

Hey Folks,

I'm curious to see who is using Lipo-C, what your dose/injection schedule is, and what your results (subjective or not) are so far.

I recently started with Defy. Dr. Saya had no problem adding Lipo-C to my regimen. (I'm dying for more energy, and also want to lose fat / maintain muscle as I diet to get back in shape).

It appears that there's a lot of flexibility in terms of how much and how often to inject Lipo-C, with the only downside to more and more often being higher cost. I've been guided to start with 1ml 2-3x per week. But the Defy website mentions a high end of 1ml every day! (see below)



How to Administer Lipo-C:
Using a 5/8" 25g or 26g needle, inject 1ml-3ml of Lipo-C twice per week.
As an alternative, Lipo-C can be injected daily. Using a 1/2" "insulin" syringe, inject 1ml of Lipo-C subcutaneously every morning.

Money is not an issue for me right now - and I'm thinking about 1ml EOD or something for the first month to kind of "kick start" things. But wanted to get your feedback first.


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Lipo-C: A Complete Guide on Lipotropic Injections for Liver Health and Fat Loss​

Lipo-C injections have become increasingly popular as an adjunct method for metabolic health and weight control. These lipotropic formulations are designed to enhance liver function, preserve muscle mass, and accelerate fat metabolism. Based on current data from Defy Medical, this guide explores the composition, mechanisms, applications, and administration of Lipo-C injections, providing a comprehensive look at this fat-burning therapy.

What is Lipo-C?​

Lipo-C is a specialized lipotropic injection intended to trigger the body's fat-burning mechanisms while maintaining lean muscle mass. "Lipotropic" compounds facilitate the breakdown of fat in the body and aid in the export of fat from the liver. Typically used in conjunction with comprehensive weight loss programs involving proper diet and consistent exercise, these injectables ensure that excess fat is converted into energy instead of being stored in tissues.

The lipotropic agents in Lipo-C assist in preventing fat storage in the liver, thereby supporting efficient fat metabolism and preserving metabolic health. When fat and bile accumulate in the liver, metabolic rates can decline, impairing the body's natural fat-burning processes.

Main Functions of Lipo-C​

Lipo-C injections serve multiple physiological functions beyond weight management:

• Enhance liver health by removing fat deposits that can impair liver function
• Improve metabolic efficiency by aiding fat-to-energy conversion
• Target stubborn fat areas (abdomen, thighs, buttocks, neck, hips)
• Deliver high bioavailability via direct bloodstream administration

Lipo-C Injection Composition​

Lipo-C typically includes a balanced mix of B vitamins, amino acids, and lipotropic agents formulated to boost fat metabolism and general health.

Key Ingredients​

1. L-Carnitine: Essential for transporting fatty acids into mitochondria where they are oxidized to produce energy.
2. Choline: Supports liver health, fat metabolism, brain development, muscle movement, and nervous system function.
3. L-Methionine: Helps maintain lean muscle mass during calorie restriction and supports protein synthesis.
4. B5 (Dexpanthenol): Assists in the breakdown of fats and carbohydrates; aids in red blood cell and hormone production.

Customized Formulations​

Different pharmacies offer variations:

• Hallandale Formula (Bio Boost Plus):
  • Methionine: 25 mg/ml
  • Inositol: 50 mg/ml
  • Choline: 50 mg/ml
  • Pyridoxine HCL: 25 mg/ml
  • Dexpanthenol: 25 mg/ml
  • Cyanocobalamin: 1 mg/ml
  • L-Arginine HCL: 15 mg/ml
  • L-Carnitine: 15 mg/ml
  • Benzyl alcohol, Lidocaine
• Empower Formula:
  • Methionine: 15 mg/ml
  • Choline: 50 mg/ml
  • L-Carnitine: 50 mg/ml
  • B5 (Dexpanthenol): 5 mg/ml

Mechanisms of Action​

Lipo-C works through key physiological mechanisms:

Fat Metabolism Enhancement​

Lipotropic agents aid fat breakdown and energy production. L-carnitine transports fatty acids to mitochondria, increasing the body’s ability to burn stored fat.

Hepatic Support​

Lipotropic ingredients stimulate lecithin production, which emulsifies fats and facilitates liver fat export. This supports liver function, controls cholesterol, and may help reduce vascular deposits.

Dosage and Administration​

Recommended Dosage​

Typical doses range from 1 to 3 ml, 2–3 times per week, tailored to body weight, metabolic rate, and treatment goals. Always follow a clinician’s guidance.

Administration Methods​

1. Subcutaneous (SubQ): Injected into fat under the skin; often used for self-administration.
2. Intramuscular (IM): Preferred for higher doses or faster absorption.

Defy Medical provides:

• Lipo-C vial
• Syringes, needles, alcohol wipes
• Sharps containers
• Self-injection training
• In-clinic administration (Tampa, FL)

Uses and Benefits​

Weight Management​

Effective in targeting resistant fat deposits when combined with diet and exercise. Injections bypass digestion, enhancing ingredient availability.

Energy and Metabolism Support​

Improves cellular energy, mood, and physical performance by converting stored fat into usable energy and supporting vitamin B metabolism.

Liver Health​

Supports enzyme production, reduces fat accumulation, and improves hepatic function. Can be used alongside therapies for liver dysfunction.

Combination Therapies​

Lipo-C can be paired with:

• B12 Injections: Enhances metabolism and energy
• B-Complex: Broader B vitamin support
• NAD+ Injections: Boosts mitochondrial energy production
• Fat-Burning Capsules: Supports multiple metabolic pathways
• LipoSculpt Cream: A topical option for localized fat loss

Use combinations under medical supervision to ensure safety and efficacy.

Pricing and Options​

Defy Medical offers several Lipo-C options:

• 10mL LIPO-C (APS or Hallandale): $59
• 10mL LIPO-C (Empower): $65
• 30mL LIPO-C (Hallandale or Empower): $99
• Fat Loss Kit (30mL LIPO-C + 10mL B12): $149

Storage Guidelines​

• Store in a refrigerator once opened
• Avoid direct light exposure
• No reconstitution required

Final Thoughts​

Lipo-C injections provide a targeted method for enhancing fat metabolism, supporting liver health, and improving energy levels. With formulations tailored to individual needs, they represent a versatile tool in metabolic health programs. Optimal results depend on proper dosing, consistent administration, and integration with a healthy lifestyle.

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Lipo-C Injections: A Detailed Briefing​

This briefing document summarizes the key themes, benefits, ingredients, administration, and user experiences related to Lipo-C injections, drawing from the provided forum discussions and informational guides.

1. Overview of Lipo-C Injections​

Lipo-C is a specialized lipotropic injection designed to support metabolic health and weight control. It is generally used as an adjunct to comprehensive weight loss programs that include proper diet and consistent exercise. The primary aim of Lipo-C is to enhance the body's fat-burning mechanisms, preserve muscle mass, and improve liver function.

Key Definitions:

• Lipotropic compounds: Substances that "facilitate the breakdown of fat in the body and aid in the export of fat from the liver."
• "MIC": Refers to three common lipotropic agents found in many Lipo-C formulations: Methionine, Inositol, and Choline.

2. Composition and Key Ingredients​

Lipo-C injections typically contain a blend of B vitamins, amino acids, and lipotropic agents. While formulations can vary between pharmacies, common key ingredients include:

• L-Carnitine: "Essential for transporting fatty acids into mitochondria where they are oxidized to produce energy."
• Choline: Supports liver health, fat metabolism, brain development, muscle movement, and nervous system function. It acts as an "energy source for the body during rapid fat and weight loss" by breaking down fat cells.
• L-Methionine: An essential amino acid that "helps maintain lean muscle mass during calorie restriction and supports protein synthesis." It also plays a key role in lipid metabolism, helping to "break down fats and cholesterol."
• Inositol: A carbocyclic sugar that can "help to improve cellular function and accelerate weight loss and fat mass reduction." It is also noted for improving insulin sensitivity, reducing inflammation, and promoting healthy hormone balance.
• B5 (Dexpanthenol): Assists in the breakdown of fats and carbohydrates, and aids in red blood cell and hormone production.
• B6 (Pyridoxine HCL): (Present in Hallandale Formula)
• B12 (Cyanocobalamin): (Present in Hallandale Formula) Often combined with Lipo-C to "enhance metabolism and energy."
• L-Arginine HCL: (Present in Hallandale Formula)

Examples of Formulations:

• Hallandale Formula (Bio Boost Plus): Includes Methionine (25 mg/ml), Inositol (50 mg/ml), Choline (50 mg/ml), Pyridoxine HCL (25 mg/ml), Dexpanthenol (25 mg/ml), Cyanocobalamin (1 mg/ml), L-Arginine HCL (15 mg/ml), Benzyl alcohol, Lidocaine.
• Empower Formula: Includes Methionine (15 mg/ml), Choline (50 mg/ml), L-Carnitine (50 mg/ml), B5 (Dexpanthenol) (5 mg/ml).

3. Mechanisms of Action​

Lipo-C works through several physiological mechanisms to achieve its purported benefits:

• Fat Metabolism Enhancement: The lipotropic agents facilitate fat breakdown and energy production. L-carnitine, for instance, transports fatty acids to the mitochondria for oxidation, thereby "increasing the body’s ability to burn stored fat."
• Hepatic Support: Ingredients like choline and methionine "stimulate lecithin production, which emulsifies fats and facilitates liver fat export." This process supports liver function by removing fat deposits, controlling cholesterol, and potentially reducing vascular deposits. This is crucial because "When fat and bile accumulate in the liver, metabolic rates can decline, impairing the body's natural fat-burning processes."
• Energy Production: By converting stored fat into usable energy and supporting B vitamin metabolism, Lipo-C aims to "improve cellular energy, mood, and physical performance."

4. Reported Benefits and Uses​

Users and medical providers report several benefits associated with Lipo-C injections:

• Weight Management: Lipo-C is considered "effective in targeting resistant fat deposits when combined with diet and exercise." It helps by "boosting metabolism and aiding in fat breakdown." Some users report losing "between two to four pounds per week" when combined with a healthy lifestyle.
• Increased Energy Levels: Many users, like "Fireproof" and "You Gonna Learn Today," subjectively report "a slight increase in energy a few hours after taking it," though some acknowledge it might be a "placebo effect." The ingredients "help to boost energy levels, making it easier to stay active and exercise."
• Improved Liver Health: Lipo-C "supports enzyme production, reduces fat accumulation, and improves hepatic function" by preventing fat storage in the liver.
• Muscle Preservation: Ingredients like L-Methionine are included to "help maintain lean muscle mass during calorie restriction."
• Improved Mood: Some individuals "report feeling happier and more relaxed after receiving Lipo C injections."

5. Dosage and Administration​

Dosage and frequency vary, highlighting the importance of clinical guidance.

• Recommended Dosage: Typical doses range from "1 to 3 ml, 2–3 times per week," adjusted for body weight, metabolic rate, and treatment goals. Defy Medical mentions a high end of "1ml every day!"
• Maximum Weekly Dose (Defy Medical): Up to 9ml/week (e.g., 3ml, 3 times per week).
• Administration Methods:Subcutaneous (SubQ): Injected into fat under the skin, often used for self-administration (e.g., "1/2" "insulin" syringe, inject 1ml of Lipo-C subcutaneously every morning"). Users like "midlifealpha" preferred this for minimizing pain.
• Intramuscular (IM): Preferred for higher doses or faster absorption. "Jon H" switched to "upper glutes, shallow IM" to avoid lumps and discomfort experienced with SubQ in the stomach. "Jackie Treehorn" found "quads" to be the easiest location for IM injection with "no burn or PIP."
• Injection Volume and Frequency: There's a discussion among users about optimal frequency vs. volume. "Jackie Treehorn" suggests "more frequency and less volume seems to work best" for him, as "pinning 3mLs of fluid in a single injection" is a lot and likely requires deep IM. "Fireproof" experimented with "smaller daily injections or larger but less frequent injections," eventually leaning towards "near-daily injections of 1mm" because he believes in the ingredients.

6. Potential Side Effects and Considerations​

While "generally considered safe," Lipo-C injections can have side effects:

• Injection Site Reactions: Common complaints include "pain or swelling at the injection site," "burning like hell going in," and leaving "a lump." "Jackie Treehorn" notes that injecting "very slowly seems to be the best technique to combat the burn."
• Systemic Side Effects: Nausea, vomiting, headache, dizziness or lightheadedness, and allergic reactions are possible.
• Odor: Several users, including "maxadvance" and "You Gonna Learn Today," reported a distinct "B vitamins" or "strange mineral/vitamin taste in my mouth" and body odor for a day after the shot, or a persistent smell if spilled.
• Crystallization: One user, "sustainedenergy," reported crystallization at the bottom layer after refrigerating, although Defy Medical's guidelines state to "Store in a refrigerator once opened."
• Not for Spot Reduction: Lipo-C injections are "not designed for spot reduction."
• Contraindications: Not recommended for those who are pregnant or breastfeeding, have liver disease, or a history of allergic reactions.
• Consistency: "Optimal results depend on proper dosing, consistent administration, and integration with a healthy lifestyle."

7. Cost and Accessibility​

• Pricing: Defy Medical offers 10mL vials ranging from $59 to $65, and 30mL vials for $99. A "Fat Loss Kit" (30mL Lipo-C + 10mL B12) is $149. HydraMed states Lipo-C injections start at "$35 per dose."
• Prescription: Obtained with a doctor's prescription, as mentioned by "Fireproof" getting his from Defy.
• Provider Support: Providers like Defy Medical offer the Lipo-C vial, syringes, needles, alcohol wipes, sharps containers, and self-injection training. In-clinic administration may also be available.

8. Combination Therapies​

Lipo-C can be combined with other therapies for enhanced effects, under medical supervision:

• B12 Injections: For "enhanced metabolism and energy."
• B-Complex: For "broader B vitamin support."
• NAD+ Injections: To "boost mitochondrial energy production."
• Fat-Burning Capsules: To "support multiple metabolic pathways."
• LipoSculpt Cream: A topical option for "localized fat loss."

9. User Experiences and Subjective Results​

Forum users provide varied subjective experiences:

• Energy Boost: Many noted a perceived energy boost, though acknowledged the possibility of a "placebo effect." "Jackie Treehorn" specifically mentioned "a blast of energy post injection."
• Weight Loss: While some like "roadglide" "have seen great results," others like "ERO" "could never see or feel anything from it." It is emphasized that results are influenced by individual factors like diet and exercise.
• Discomfort/Lumps: Issues with injection site pain and lumps were reported, particularly with larger volumes (e.g., 1mL+) or in certain areas like the abdomen or deltoids.
• Odor: A distinctive vitamin-like smell was a common observation.
• Individual Variation: Users frequently highlighted that "we are all different" and encouraged experimentation to "find out what works best for you" regarding dosage and injection frequency.

 

I am actually not sure myself. I use 1.5 ml twice per week currently due to some griping I saw about pain. (minimizing injections).

I use the Defy sent .25 gauge Sub-q (5/8) needles. Since I switched to a .27 gauge needle for T-injections I figured I'd get use out of those needles to prevent the surface pain some have described.

I don't know that I feel that much different yet I've had mine about 3 weeks?

 

I have used this in the past and could never see or feel anything from it. I know its not a 'magic shot' for instant weight loss or energy, but still...never felt anything...perhaps its just me.

 

I use Lipo-C 5-7 times per week. Dose is 1ml, using a 29g 1/2" insulin syringe. When I first started I was doing SubQ in stomach and sides. This made me "lumpy" and was uncomfortable. I switched to upper glutes, shallow IM, and it's been great.

 

Thanks for the feedback so far guys.

Anyone else?

 

I am interested in Lipo-C as well, what is the cost? Any luck with weight loss?

 

I am interested in Lipo-C as well, what is the cost? Any luck with weight loss?

Depending on where you get it, it's around $76-100 per 30ml vial. I get mine from Defy for $76 with the Doc's prescription. Here's a write-up on the expected benefits:
http://defymedical.com/video-education/health-articles/1-the-next-generation-of-fat-loss-injections

I just started, so time will tell on the weight loss. I'm aggressively dieting right now, and I know the biggest factor is "calories in vs. calories out" - but if this can boost my energy, accelerate some fat loss, and help preserve lean tissue - it's worth a short term investment to me...then I'll re-evaluate if I want to continue when I get to "maintenance."

 

I think I may have already told you before, but I'm pinning 1mL EOD into my quads. I've pinned this nutrient in every possible location, and this is the result:

Abdomen - burned like hell going in, and I can't take more than .5mLs without it leaving a lump.

Deltoids - burned like hell going in, 1mL left a big lump, and my shoulder was sore for 3 days.

Glutes - no burn or any PIP. The only problem is the difficulty pinning myself in this area.

Quads - no burn or PIP. Easiest location for me to pin. This is my "go to" spot.

The Lipo-C seems to give me a blast of energy post injection. Injecting very slowly seems to be the best technique to combat the burn.

 

Question for you guys. Any ideas on Half-Life of the key elements in Lipo-C?

I've seen dosing frequencies of daily, EOD, and 3x/week. Defy told me I can inject daily or 2-3 times per week in various amounts (1-3ml) as long as I don't exceed 9ml/week (calculated from 3 times per week at 3ml/injection).

Trying to figure out if I should do smaller daily injections or larger but less frequent injections.

Any comments?

 

Trying to figure out if I should do smaller daily injections or larger but less frequent injections.

Any comments?

FP,

You're going to have to turn yourself into a lab rat, and find out what works best for you. Personally, I can't imagine pinning 3mLs of fluid in a single injection. That is a lot of fluid, and you're not going to be able to do that much SubQ.

I know it's a pain in the ass, but more frequency and less volume seems to work best (at least for me). I don't want to inject deep IM, and that's what you're going to have to do if you're thinking of injecting a large amount like 3mLs. Let us know how it pans out.

 

I did 1ml twice a week in the beginning, subq insulin pin in the belly, honestly didn't feel much of anything. Another downside is that your whole body reeks of B vitamins for a day after the shot.

 

Thanks guys. Interesting how we are all different, and I have no problem being a lab rat in that respect.

Here are some things I've tried:
- Tried injecting 1mm in multiple spots and had no issues in quads or belly subQ. I could feel a little bump for a while in the belly, probably due to 1mm being a lot of liquid, but no pain.
- Tried 2mm dose one day (2 separate 1mm injections - 1 in each quad) - and seemed to feel more of an energy boost that day. (Not sure if placebo effect though).
- Tried a week of daily 1mm shots for a week. Felt pretty good all week. (Not sure if placebo, and plus so many other things are in play, how can you really isolate?)
- Never noticed any smell or changes in body odor.

FWIW, YMMV, and all that.

I'll likely continue with probably near-daily injections of 1mm, since I believe in the ingredients. But after a couple months (after I've lost some more body fat) I'm likely going to taper off and stop and see if I notice any difference.

 

I just started taking Lipo-C from Defy early last week. I pin 1ml EOD and I can say I've noticed a slight increase in energy a few hours after taking it (like Fireproof, not sure if placebo affect as well). I may try the 2ml as separate pins on separate quads (I've only pinned quads to this point) to see if that does more for me. I may also switch to daily pins, to see if that helps as well. So far, I've lost about 5 lbs since originally starting it, but I'm not sure how much of that is related to TCyp, my changed diet, exercise, or Lipo-C. I do know, however, that this combination is working for me and I'm feeling really good, so I plan on continuing to take it but will see what dose and frequency works best for me.

I notice the odor, but for me I only smell it on my hands and spot where I pin so I wash my hands thoroughly after I'm done. I actually prepared my injections on my ironing board one time next to a couch in my room. I must have dropped a bit because I can still smell it from that time over a week and a half ago. The first day I took it, I did notice a strange mineral/vitamin taste in my mouth. But I have not noticed it since.

I'll post my findings once I figure out what has the best effect.

 

I just started on lipo-c today, 1 ml 2x a week. I was surprised at how much 1 ml really is! I injected it sub-q into my abdomen and didn't have any issues. Y'all are definitely right about the smell, it is pretty potent. I'm definitely looking forward to seeing any changes.

 

I received my Lipo-C this week and started it. I must have made a mistake by refrigerating it as I now can see the bottom layer has crystalized.

 

I've just started Lipo-c today as well. I'm injecting SQ 1ml per day.

 

Sound like more of an energy boosts then weight lose. Anyone else notice a weight loss benefit?

 

I'm hoping for weight loss benefit too - I'd be interested in hearing if others had this effect. Just started today and was planning 1ml 3x week.

 

I use it and have seen great results.

 

I use it and have seen great results.

weight loss?