Issues with cypionate causing heart pounding

[Fortunate]

I experience similar sensations, depending on what form of TRT I am using. You might consider trying a different form or changing up the dosing and/or frequency like others suggested.

This tends not to be an issue for me with things like Natesto.

It’s worth trying something else such as a cream or Natesto see if you can get symptom relief without the bounding pulse.

For some reason, I think some have a sympathetic nervous system that is more sensitive to androgens than others. I tend to be one of them, I believe.

Finally, maybe check your thyroid. It is possible that it could be playing a role.

 

[transetpmedia]

I experience similar sensations, depending on what form of TRT I am using. You might consider trying a different form or changing up the dosing and/or frequency like others suggested.

This tends not to be an issue for me with things like Natesto.

It’s worth trying something else such as a cream or Natesto see if you can get symptom relief without the bounding pulse.

For some reason, I think some have a sympathetic nervous system that is more sensitive to androgens than others. I tend to be one of them, I believe.

Finally, maybe check your thyroid. It is possible that it could be playing a role.

Unfortunately Natesto isn't an option for me, doesn't tend to be used in the UK. I should be able to get cream, have you ever tried it?

 

[Fortunate]

Unfortunately Natesto isn't an option for me, doesn't tend to be used in the UK. I should be able to get cream, have you ever tried it?

Yes. Cream and I have a bit of a love-hate relationship. It can be a wild pony to tame, but for many, it’s an excellent treatment option.

If you’re not careful, you can skyrocket your testosterone and DHT level with cream. But, it still may be worth trying. If you can get a compounded cream, you can titrate the dose to your needs. Just watch your symptoms and labs closely. It may be worthwhile in order to isolate what might be causing your pounding feeling. Also, it’s relatively short half-life allows you to back off much quicker than injections if you are supraphysiologic.

I suspect this might also give you a similar feeling, but it’s a relatively safe experiment. You would have to give yourself a few weeks of allowing your esters to clear before the experiment would be worthwhile.

You can consider a very low dose beta blocker to help with the cardiovascular feelings, but those come with a number of unwanted side effects and in someone your age, I doubt you’d want to do this.

Let us know how it goes.

 

[transetpmedia]

Yes. Cream and I have a bit of a love-hate relationship. It can be a wild pony to tame, but for many, it’s an excellent treatment option.

If you’re not careful, you can skyrocket your testosterone and DHT level with cream. But, it still may be worth trying. If you can get a compounded cream, you can titrate the dose to your needs. Just watch your symptoms and labs closely. It may be worthwhile in order to isolate what might be causing your pounding feeling. Also, it’s relatively short half-life allows you to back off much quicker than injections if you are supraphysiologic.

I suspect this might also give you a similar feeling, but it’s a relatively safe experiment. You would have to give yourself a few weeks of allowing your esters to clear before the experiment would be worthwhile.

You can consider a very low dose beta blocker to help with the cardiovascular feelings, but those come with a number of unwanted side effects and in someone your age, I doubt you’d want to do this.

Let us know how it goes.

It's the only alternative option I have other than gel, but from what I gather if you can get cream you may as well do it over the gel. I will probably give the cream a shot but I don't feel hopeful about it to be honest because I know some people get bad sides from it.

 

[Willyt]

If I go lower it reduces but I don't feel good. I mentioned in other posts, but with 1100ngdl test on clomid I didn't have this problem, which suggests it isn't the test?

This is the balancing act with TRT. I would love to be on higher T dose, but trade-off is not worth it.

 

[Russo]

Do you know why the cypionate would cause me problems when on clomid my levels were 50% higher but I didn't have any issues?

Sorry but I don't know, my brother. I am having problems with T injections too (low libido). I just reply the thread about the BA/BB confusion because I know they are not the culprits of your side effects. They are just in the formula to hold the solution and protect you from getting an infection.

Hope you can find and fix for your problem(s). Wish you the best.

 

[Fortunate]

Sorry but I don't know, my brother. I am having problems with T injections too (low libido). I just reply the thread about the BA/BB confusion because I know they are not the culprits of your side effects. They are just in the formula to hold the solution and protect you from getting an infection.

Hope you can find and fix for your problem(s). Wish you the best.

It’s theoretically possible that the preservatives are causing a problem, but unlikely. One way to test the theory would be to Xyosted. It does not have preservatives. It would be an expensive experiment if it’s not covered by insurance.

 

[Cynice49]

Have had the same symptoms pretty much for the entirety of my TRT treatment. Been on trt for about 6 years, various doses with the longest being 15-16mg daily subq for the past 2 years , I’ve dropped down to 10mg daily….. and really nothing has helped. Along with the bounding pulse, I feel a constant anxiety feeling that comes and goes with on occasional wave of panic. The bounding pulses pretty much occur all the time, with a large increase in my heart rate when I stand. (I hate to believe in the pots phenomenon, but my sx match hyperadrenergic pots pretty well) I’m currently trying a trial of pregnenolone and progesterone in hopes that solves some of my issues, but after 6 years of trying to deal with this I’m pretty much to the end of what I want to continue with. If this doesn’t help I’ll probably hop off and go on a cycle of clomid/enclomip for a bit.

 

[Fortunate]

I think this is more common than we think. I have experienced it as well. The few things that were helpful: Using Natesto or using a beta blocker with your current protocol.

Beta blockers are great drugs, but for some, they can come with unacceptable side effects (lethargy, depression, libido hit). Natesto is a great option, but many guys aren't willing to try it.

 

[Cynice49]

I actually had used 10-20mg propranolol up to 3 times daily, I would use often three times daily for about a year but it affected my lipid profile terribly. I thought about switching to Nebivolol but I don’t think my primary would Rx it (propranolol was prescribed for anxiety sxs).

I have thought about Natesto, currently under care with a urologist so test cyp, ai, HCG is pretty much my choices until I end up switching to a clinic or something.

But I agree, I do think this issue occurs more often. I’m not sure whether it’s due to the vasodilation effects of trt, or another hormonal pathway we’re not covering. I would think if it were from the vasodilation effects, it would decrease blood pressure (which I’m sure it does in some). I’m very vascular since I’ve gotten on trt, but my blood pressure has increased +20/+10 and eventually starting on telmisartan.

 

[Fortunate]

I actually had used 10-20mg propranolol up to 3 times daily, I would use often three times daily for about a year but it affected my lipid profile terribly. I thought about switching to Nebivolol but I don’t think my primary would Rx it (propranolol was prescribed for anxiety sxs).

I have thought about Natesto, currently under care with a urologist so test cyp, ai, HCG is pretty much my choices until I end up switching to a clinic or something.

But I agree, I do think this issue occurs more often. I’m not sure whether it’s due to the vasodilation effects of trt, or another hormonal pathway we’re not covering. I would think if it were from the vasodilation effects, it would decrease blood pressure (which I’m sure it does in some). I’m very vascular since I’ve gotten on trt, but my blood pressure has increased +20/+10 and eventually starting on telmisartan.

Nebivolol is supposed to have less sedating and libido affects. It might be a good option if you have those side effects. Reasonable to ask your prescribing physician, particularly since you are on an ARB.

 

[tareload]

Look into escitalopram (lexapro) if you are sensitive to even modest dosing of Test or want to run higher due to mental illness/body dysmorphia. See my posts on escitalopram and autonomic/sympathetic regulation. Game changer for me.

The Case Against Antidepressants

Glad you got it figured out. I hope one day to reach that level of enlightenment. Thanks for the hope. No worries man you do you. Given the choice between klonopin and lexapro I think you made the right choice.

www.excelmale.com

Metoprolol/propanolol did not make a dent so I must conclude for me it was brain/heart connection.

 

[Fortunate]

Look into escitalopram (lexapro) if you are sensitive to even modest dosing of Test or want to run higher due to mental illness/body dysmorphia. See my posts on escitalopram and autonomic/sympathetic regulation. Game changer for me.

The Case Against Antidepressants

Glad you got it figured out. I hope one day to reach that level of enlightenment. Thanks for the hope. No worries man you do you. Given the choice between klonopin and lexapro I think you made the right choice.

www.excelmale.com

Metoprolol/propanolol did not make a dent so I must conclude for me it was brain/heart connection.

I actually may consider this, too. Any idea why Lexapro would be useful for this as opposed to any other SSRI?

Any unpleasant side effects from it (I know it can be associated with emotional blunting, libido, drop, etc.)?

 

[tareload]

I actually may consider this, too. Any idea why Lexapro would be useful for this as opposed to any other SSRI?

Any unpleasant side effects from it (I know it can be associated with emotional blunting, libido, drop, etc.)?

see here.

The Case Against Antidepressants

This article describes my experience thus far: https://academic.oup.com/ijnp/article/18/5/pyu053/784635 Good thing I listened to my Doctor. Now I can enjoy destroying the gym once again and QOL has improved significantly. Knock on wood it has only been a few months. @Fortunate...

www.excelmale.com

Should not be unique to escitalopram. Sertraline for example Should work. Escitalopram just happens to be a very sharp instrument selectivity wise.

Oh yes. A Faustian bargain. Lower professional motivation, higher depression. Sexual sides.

But anything beats before. Also cure any porn addiction. Can not get an erection from porn but still works with partner.

In summary, gotta set your priorities and which muscles are important. Just bumped up to 160 mg/week but still small.

May have gone backwards from a few months ago...

My perspective unreliable.

Happy Father's Day Gents!

 

[tareload]

See here as well.

The Case Against Antidepressants

Glad you got it figured out. I hope one day to reach that level of enlightenment. Thanks for the hope. No worries man you do you. Given the choice between klonopin and lexapro I think you made the right choice.

www.excelmale.com

 

[Fortunate]

See here as well.

The Case Against Antidepressants

Glad you got it figured out. I hope one day to reach that level of enlightenment. Thanks for the hope. No worries man you do you. Given the choice between klonopin and lexapro I think you made the right choice.

www.excelmale.com

I'll dig in. Thanks.

Mood was one of the many symptoms I have been trying to "treat" with TRT. As is well documented, I have had a hard time nailing down a tolerable TRT protocol (@Charliebizz, hold your fire, my brother ). So, I decided that maybe I should be attempting to attack mood from another angle. So, I actually started sertraline a few weeks ago.

The most challenging thing I have noticed is overwhelming fatigue that happens in the middle of the day - like 11AM to 2PM or so - every day. I am not 100% that it's from the sertraline, but I am virtually certain. It's the only variable I can think of that may be causing it. Only other variable is that I have been on cream. I suppose it's possible my levels drop that time of day, but really doubt it based on recent labs.

But, I digress. Don't want to hijack too much of this thread.

 

[tareload]

I'll dig in. Thanks.

Mood was one of the many symptoms I have been trying to "treat" with TRT. As is well documented, I have had a hard time nailing down a tolerable TRT protocol (@Charliebizz, hold your fire, my brother ). So, I decided that maybe I should be attempting to attack mood from another angle. So, I actually started sertraline a few weeks ago.

The most challenging thing I have noticed is overwhelming fatigue that happens in the middle of the day - like 11AM to 2PM or so - every day. I am not 100% that it's from the sertraline, but I am virtually certain. It's the only variable I can think of that may be causing it. Only other variable is that I have been on cream. I suppose it's possible my levels drop that time of day, but really doubt it based on recent labs.

But, I digress. Don't want to hijack too much of this thread.

Give it at least a few months on the SSRI. First 4 weeks were really rocky. After that the anxiety really subsided. I will take depressed and emotionally blunted over panic / anxiety every time.

But you gotta know how to deal with depression. I have lots of practice. SSRIs should be called depressants instead of antidepressants. Definitely suppress anxiety and depress mood for me.

 

[Fortunate]

Give it at least a few months on the SSRI. First 4 weeks were really rocky. After that the anxiety really subsided. I will take depressed and emotionally blunted over panic / anxiety every time.

But you gotta know how to deal with depression. I have lots of practice. SSRIs should be called depressants instead of antidepressants. Definitely suppress anxiety and depress mood for me.

I do feel less anxious (I am also tightly wound). But, the fatigue is unacceptable for me. Maybe with time it will subside? For now, I am actually titrating down - primarily to troubleshoot the cause of the fatigue with the idea that I can always go back up and/or restart.

Some say the combo of Zoloft and Wellbutrin compliment may be worth trying. Have you ever considered?

 

[Gman86]

Have had the same symptoms pretty much for the entirety of my TRT treatment. Been on trt for about 6 years, various doses with the longest being 15-16mg daily subq for the past 2 years , I’ve dropped down to 10mg daily….. and really nothing has helped. Along with the bounding pulse, I feel a constant anxiety feeling that comes and goes with on occasional wave of panic. The bounding pulses pretty much occur all the time, with a large increase in my heart rate when I stand. (I hate to believe in the pots phenomenon, but my sx match hyperadrenergic pots pretty well) I’m currently trying a trial of pregnenolone and progesterone in hopes that solves some of my issues, but after 6 years of trying to deal with this I’m pretty much to the end of what I want to continue with. If this doesn’t help I’ll probably hop off and go on a cycle of clomid/enclomip for a bit.

I wouldn’t give up on HRT man. I would do so many things before doing that. Definitely try optimizing diet, sleep, stress and exercise the best that u can before giving up. U’d be extremely surprised how fast anxiety can subside when u optimize ur diet. And when I say optimize ur diet, I mostly mean just cutting out things that mess with ur body, and only give it things that help the body and give it the micronutrients it needs to function properly. 99.999999% of people that think they’re eating healthy aren’t. I can always find multiple things that someone is ingesting that is messing with their body bigtime, whenever they say they eat healthy and I ask what their diet consists of. I could honestly post hundreds of anecdotes where people are talking about how optimizing their diet completely got rid of their depression and/ or anxiety. A lot of the people report lifelong depression and anxiety going away too. And many people that had been diagnosed with treatment resistant depression. U wouldn’t believe how easy it is for most people to get rid of their anxiety and/ or depression once they figure out the true way to eat properly. And even if ur anxiety started once u went on HRT, it still doesn’t mean HRT is the issue. The same HRT protocol can effect someone drastically different depending on the person‘s overall health, and the state of their body apart from their hrt protocol. I’ll post an anecdote of people curing their mood issues with diet using both carnivore and raw veganism, just to show that Im not married to the idea that theirs only one way to eat to optimize overall health. I believe it’s more about the things u don’t ingest that will mess with the body, than what u do ingest

(watch from 16 mins to 18 mins)

(watch from 3:50 to 4:50)

 

[Fortunate]

I wouldn’t give up on HRT man. I would do so many things before doing that. Definitely try optimizing diet, sleep, stress and exercise the best that u can before giving up. U’d be extremely surprised how fast anxiety can subside when u optimize ur diet. And when I say optimize ur diet, I mostly mean just cutting out things that mess with ur body, and only give it things that help the body and give it the micronutrients it needs to function properly. 99.999999% of people that think they’re eating healthy aren’t. I can always find multiple things that someone is ingesting that is messing with their body bigtime, whenever they say they eat healthy and I ask what their diet consists of. I could honestly post hundreds of anecdotes where people are talking about how optimizing their diet completely got rid of their depression and/ or anxiety. A lot of the people report lifelong depression and anxiety going away too. And many people that had been diagnosed with treatment resistant depression. U wouldn’t believe how easy it is for most people to get rid of their anxiety and/ or depression once they figure out the true way to eat properly. And even if ur anxiety started once u went on HRT, it still doesn’t mean HRT is the issue. The same HRT protocol can effect someone drastically different depending on the person‘s overall health, and the state of their body apart from their hrt protocol. I’ll post an anecdote of people curing their mood issues with diet using both carnivore and raw veganism, just to show that Im not married to the idea that theirs only one way to eat to optimize overall health. I believe it’s more about the things u don’t ingest that will mess with the body, than what u do ingest

(watch from 16 mins to 18 mins)

(watch from 3:50 to 4:50)

Appreciate the thoughts. My bad - I wasn’t clear. I am tapering the SSRI, not TRT!

The gut is and diet are definitely important!