Is it best to try to always stay in natural ranges?

Jistec

New Member
I'm just wondering if, barring an exceptional circumstance, it's best to always stay in natural ranges on trt. I was thinking daily shots (stopping my peak from being supraphysiological) and keeping me below 1000 total T, e2 in a natural range, dht within lab ranges, etc was kind of the point of trt. Lately I've been seeing a lot of people using the cream which puts their total T at like 1800 or higher, their e2 in the 70s or 80s, and their Dht 5 times above normal. Is that really necessary or is it even "trt" at that point?
 
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I'm just wondering if, barring an exceptional circumstance, it's best to always stay in natural ranges on trt. I was thinking daily shots (stopping my peak from being supraphysiological) and keeping me below 1000 total T, e2 in a natural range, dht within lab ranges, etc was kind of the point of trt. Lately I've been seeing a lot of people using the cream which puts their total T at like 1800 or higher, their e2 in the 70s or 80s, and their Dht 5 times above normal. Is that really necessary or is it even "trt" at that point?
I would have to say yes. It's better for most to stay in your natural range. It would be nice, if I would have done my labs when I was in my twenties. Then I would really know what my natural ranges were. It may not be the same for everyone though, trt is very individual. It seems that guys who do testosterone cream, do better with higher DHT.
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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