I wish I was smart enough to understand Cataceous’ explanation of how SHBG works. But the reason that I’ve seen that low SHBG guys maybe have to inject more frequently is because they’ll take a shot of say 100mg, and their total T will shoot up to say 1000 very quickly, and then drop down to say 400-500 in just a couple days. Opposed to a high SHBG guy like myself, where if I take that same 100mg shot, my total T will go up to say 1000, and then stay around that for longer, and then will maybe get To around 400-500 after 5-7 days, opposed to the low SHBG guy that will have those trough levels after just a couple days. Low SHBG guys will have a more rapid peak and trough, and therefore will need to inject more frequently to avoid the drastic ups and downs. Now why this happens with low SHBG men, I honestly don’t know, I just know what I’ve seen with men’s bloodwork that have low and high SHBG levels.