Ideal IGF-1 Level?

McBeavy

Member
Back in May of 2019 I had my IGF-1 tested and the results were 103 (100-300 ng/mL), which seemed low. This was pre Test replacement. I started T replacement in September/2019 (I'm on 100mg Test Cyp/week) and didn't really think about the IGF-1 further

Recently, I thought about starting an Ipamorelin/CJC combo peptide as I'm 52 and wanted to enjoy the benefits of higher growth hormone and remembered I was kind of low back in 2019.

But before I started peptide therapy, I wanted to get my IGF-1 tested again. It came back, surprisingly, at 223 (100-300 ng/mL).

Can T replacement cause this rise? And what is an ideal IGF-1 level? The information I've found is all differing levels.
 
Here's a good thread by Nelson.

 
I wanted to get my IGF-1 tested again. It came back, surprisingly, at 223 (100-300 ng/mL).
A few years ago I tried peptides and got no increase at all in IGF-1, actually it went down and then I found out I had been living with iron deficiency for 2-3 years, started iron supplements and IGF-1 increase from 149-189 after years of trying to get it to increase.

Can T replacement cause this rise? And what is an ideal IGF-1 level?
Yes, TRT can increase your IGF-1 level and I can only wonder if it's somehow by the same mechanism iron-> HCT -> thicker blood.
 
my IGF-1 was way below 100. once I started IF+KETO+weight training i went up to 233 and has been steadily holding in the mid 200's
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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