I get anxiety when using hCG with TRT

[Tman]

I've tried starting HCG several times over the last two years with similar results. By day 7 I start to have anxiety from it. I've tried 500 eod, 350, and 250 with the same results. I keep trying because it helps with my mood and well being the first couple of days. The doc seemed stumped, but I told him I stopped it. He didn't seem concerned. Thoughts

 

[Cataceous]

At least for me, the saturation dose of hCG for estradiol production is relatively low. This means that when taking anywhere from 470-1,050 IU per week I see a rise of nearly 20 pg/mL in estradiol. If estradiol is contributing to your anxiety then this may be the reason. Conventional wisdom says that 500 IU per week is about the minimum needed to maintain benefits. Yet there are anecdotal reports of guys taking only 250 IU once a week with reasonable results. If you'd like to continue using hCG then you may need to experiment with lower doses.

 

[DS3]

I've tried starting HCG several times over the last two years with similar results. By day 7 I start to have anxiety from it. I've tried 500 eod, 350, and 250 with the same results. I keep trying because it helps with my mood and well being the first couple of days. The doc seemed stumped, but I told him I stopped it. He didn't seem concerned. Thoughts

I experienced profound anxiety with compounded HCG from Empower, but since I switched to Novarel I have had zero of the negative subjective symptoms (anxiety, etc.). I used Empower on and off for 2 years before switching to Novarel. Have been using Novarel for about a year and would never even consider going back.

It may be estradiol related. However, it may be worth switching brands to see if there is a subjective difference in response.

 

[Tman]

I experienced profound anxiety with compounded HCG from Empower, but since I switched to Novarel I have had zero of the negative subjective symptoms (anxiety, etc.). I used Empower on and off for 2 years before switching to Novarel. Have been using Novarel for about a year and would never even consider going back.

It may be estradiol related. However, it may be worth switching brands to see if there is a subjective difference in response.

What is Novarel.

 

[Vince]

What is Novarel.

Hcg novarel??

Hi All, I've been on Hcg pregnyl since starting TRT back in April. I just called my pharmacy to refill and they said there is a national shortage on Hcg pregnyl and suggested novarel. Does anyone have any experience with that product? Thanks

www.excelmale.com

 

[Vince]

I've tried starting HCG several times over the last two years with similar results. By day 7 I start to have anxiety from it. I've tried 500 eod, 350, and 250 with the same results. I keep trying because it helps with my mood and well being the first couple of days. The doc seemed stumped, but I told him I stopped it. He didn't seem concerned. Thoughts

I would start with 100 mg of HCG once a week. If it goes good from there, you can increase your dose. You could even start lower. 50 mg once a week, if it goes good you can move to twice a week.

 

[DS3]

I would start with 100 mg of HCG once a week. If it goes good from there, you can increase your dose. You could even start lower. 50 mg once a week, if it goes good you can move to twice a week.

At that dosage, the limited data that we do have would suggest minimal if any benefit at all would be obtained.

Preserving fertility in the hypogonadal patient: an update - PMC

An increasing number of young and middle-aged men are seeking treatment for symptoms related to deficient levels of androgens (hypogonadism) including depression, loss of libido, erectile dysfunction, and fatigue. The increase in prevalence of ...

www.ncbi.nlm.nih.gov

 

[Vince]

At that dosage, the limited data that we do have would suggest minimal if any benefit at all would be obtained.

Preserving fertility in the hypogonadal patient: an update - PMC

An increasing number of young and middle-aged men are seeking treatment for symptoms related to deficient levels of androgens (hypogonadism) including depression, loss of libido, erectile dysfunction, and fatigue. The increase in prevalence of ...

www.ncbi.nlm.nih.gov

Apparently higher doses of hCG causes you issues. Some members need to use lower doses. You have nothing to use by trying or if you happy, just use none.

 

[DS3]

I would start with 100 mg of HCG once a week. If it goes good from there, you can increase your dose. You could even start lower. 50 mg once a week, if it goes good you can move to twice a week.

At that dosage

Apparently higher doses of hCG causes you issues. Some members need to use lower doses. You have nothing to use by trying or if you happy, just use none.

I take 500 IU 2-3 times weekly and feel good. I agree that @Tman has nothing to lose per se from trying 50-100 IU weekly, but with the current data one could infer he will likely also receive no benefit from doing so.

 

[Vince]

At that dosage

I take 500 IU 2-3 times weekly and feel good. I agree that @Tman has nothing to lose per se from trying 50-100 IU weekly, but with the current data one could infer he will likely also receive no benefit from doing so.

I inject 500 IU twice a week. We have to find what works for us.

 

[Tman]

I would start with 100 mg of HCG once a week. If it goes good from there, you can increase your dose. You could even start lower. 50 mg once a week, if it goes good you can move to twice a week.

I might give that a try, even though Dr. Saya's minimal research indicates higher doses are needed. I tend to over respond to meds... Ed 18mg test gave me 48 ft at trough...once I stsbilize wi th my latest protocol change, I might try the low dose.

 

[Vince]

I might give that a try, even though Dr. Saya's minimal research indicates higher doses are needed. I tend to over respond to meds... Ed 18mg test gave me 48 ft at trough...once I stsbilize wi th my latest protocol change, I might try the low dose.

Ex-member of excelmale and a patient of defy Medical. I believe he use 100 IU of HCG once a week and twice a week. He could never tolerate more.

 

[Gman86]

I experienced profound anxiety with compounded HCG from Empower, but since I switched to Novarel I have had zero of the negative subjective symptoms (anxiety, etc.). I used Empower on and off for 2 years before switching to Novarel. Have been using Novarel for about a year and would never even consider going back.

It may be estradiol related. However, it may be worth switching brands to see if there is a subjective difference in response.

Where do u get ur novarel from, and how much are u paying for it?

 

[Gman86]

@DS3 also, did u notice any differences in regards to labs with Empower’s HCG and novarel?

 

[Gman86]

@Nelson Vergel so what’s going on with HCG? Is it basically going to be unavailable at the end of the year? I’m just wondering if I should try out different brands of HCG to see if I get better results from them, or if that’s pointless because at the end of the year I won’t even be able to get them anymore, and if I should just be patient and then focus on dialing in with kisspeptin once it’s available?

What do u plan on doing once empower’s HCG isn’t available anymore? I know that’s the brand that u currently use, and have used for quite some time

 

[Nelson Vergel]

Brand names will still be available. I will use GoodRx.com coupons then. Empower may also sell brand names if they lose the lawsuit.

 

[DorianGray]

I have not seen any updates about the status of HCG regulation. Anyone know when a decision is supposed to come? Also, if it does become scarce, perhaps some of the Indian or Sri Lanka pharma manufacturers might start making it (?)

 

[Nelson Vergel]

Here is a thread that summarized the drama

The FDA Ended Your Access to More Economical hCG and FSH

UPDATE ON DECEMBER 1, 2021: The FDA has just made it a lot more difficult for couples seeking fertility to start a family. They have shut down the only affordable access to fertility hormones made by compounding pharmacies for over 40 years . All compounders were ordered to stop making...

www.excelmale.com

 

[Cataceous]

... I should just be patient and then focus on dialing in with kisspeptin once it’s available?
...

What have you heard about kisspeptin? What I've learned so far makes me think that it will require concurrent use of a SERM for guys on TRT. Otherwise, even if it stimulates GnRH production it may not yield gonadotropins—LH and FSH.

 

[Nelson Vergel]

Gonadorelin alternative to hCG - Kisspeptin a peptide that is not approved for compounding

After doing some digging since a clinic i know is no longer using hCG, a called a few pharmacies and found out they are going to be offering Gonadorelin and NOT Kisspeptin. Kisspeptin is a peptide and it is NOT approved to be compounded and states like California will not approve it, while...

www.excelmale.com