High SHBG

Anyone with elevated SHBG - there is genetic causes of this but also a common cause is iron overload Hemochromatosis. If it were me, I would be getting a full iron panel with ferritin and saturation. This is my issue as well and I have iron overload. Liver iron overload is associated with elevated SHBG concentration and moderate hypogonadotrophic hypogonadism in dysmetabolic men without genetic ... - PubMed - NCBI

Very interesting. I’ve been getting a bunch of blood drawn for my labs, usually 5 times per year, and I get a ton of labs drawn each time. I also donated blood about 3 months ago. I bottomed out my iron levels unfortunately. Currently trying to build them back up. Bottoming out my iron levels unfortunately didn’t lower my SHBG one bit. Everyone’s obviously different, but at least with me, having very low iron levels didn’t seem to lower my SHBG at all.
 
There is a YT video out there with Dr Crisler talking about his T protocol to bust through a high SHBG then how to maintain vs protocol for a low SHBG person. Obviously, they were polar opposite protocols. I don't have a link.
 
Very interesting. I’ve been getting a bunch of blood drawn for my labs, usually 5 times per year, and I get a ton of labs drawn each time. I also donated blood about 3 months ago. I bottomed out my iron levels unfortunately. Currently trying to build them back up. Bottoming out my iron levels unfortunately didn’t lower my SHBG one bit. Everyone’s obviously different, but at least with me, having very low iron levels didn’t seem to lower my SHBG at all.


I don't think it works the other way, low iron =low shbg but high iron can = high shbg With people that have iron overload, treatment does not seem to lower shbg unfortunately. Maybe sometimes it does , who knows.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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