High shbg, low free test , huge estradiol after test e

Marin3112

New Member
My doc put me on test. e (350mg/weekly - too much I know now) because low free t…After 4 days on testosterone enanthate i feel really depressed and tired, low sex drive and my nipples itching like hell!!!

High shbg, borderline high Tsh , low hgh, low free t…
I’m skinny guy - underweight , almost zero fat . weight 75kg (165lb) , height 189cm (6,2). I lost lot of muscle mass because I have digestion problems (sibo) …poor digestion , lack of sleep, constipation … before my first injection i didn’t feel depressed at all - but after injection this is really strong depression - no motivation for anything,brain fog,sexdrive -zero!!!

Then I took low dose arimidex 0.30 mg and quit test... Again mistake -nipples itching disapper but after that i feel really depressed , itchy and paint in joints , really bad feeling ....it lasted for five days- first I thought - estrogen crash but today I got my bloodwork and my estradiol levels is sky-rocket 400 411 pmol/l ( 94-223). Total test , free test same like before test and arimidex...what now? How it possible? Huge estradiol levels but on Arimidex I feel like I die, I definitely have high aromatase activity but this e2 levels this is not normal…..next steep - all I want to feel better...any suggestion? How to lower shbg , how to lower estrogen but without arimidex and put test to normal levels...this is so complicated!! Please any suggestion?!


Before test
1.testosterone 27.28 (8.64-29.0)
2.low free testosteron 27.43 (33.8-106)
3.high Shbg - 96 (14-47)
4. High normal TSH (4)
Ft4 -12.4 (11.5-22.7)
Ft3 5.50 (2.3-6.3)
HGH 0.5 (<7. 41) - really low
IGF-1 15.7 (7.4-31.3)
Cortisol - 8am 714 (171-536)
E2- 128 nmol/l (99-192)
HCG <0.1 (0-2.6)
Vitamin D 59.8 nmol/l (>75) -low
--------------

After 350mg test and 0.3mg arimidex my levels:
E2 411 pmol/l (94-223)!!!
Testosterone 25.58 nmol/l (8.64-29.0)
Free test 33.56 (33.8-106)

Ast 24 (11-38)
Alt 39 (12-49)
Ggt 34 (11-55)
 
I agree with the others, your doctor has no idea what he's doing. I would find a good thyroid doctor and get a thyroid panel, TSH, free T4, free T3, reverse T3 and antibodies.
 
Thanks Vince....my Tsh is quite high 4.00 ..
Does estrogen dominance cause Hypothyroidism or does Hypothyroidism cause estrogen dominance?
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
0
Guests online
399
Total visitors
399

Latest posts

Back
Top