There are suggestions that high E2 can lead to high prolactin in some cases and yes... high prolactin symptoms mirror many of the same symptoms associated with high E2. High prolactin (in the 20s and above) will kill erections in most guys. Prolactin naturally rises after orgasm... makes you to wish your girlfriend would turn into a pizza after sex and why you're not ready to blow another load immediately after (the refractory period). Some guys take Caber to minimize the refractory period (Loki I believe). Cuddling kittens and babies will will raise your prolactin as well so stay away from them!