Guided_by_Voices
Well-Known Member
High-dose Niacin was generally considered very beneficial before about 2010 but then fell into a bit of disfavor without much credible change in the science. I have been watching the evidence for a long time and it seems incomplete but generally positive. I have tried niacin on and off without conclusive results in terms of overall well-being or lipid numbers, but when a doctor recommended it to reduce very slightly elevated triglyceride numbers I gave it a more determined try. I went through a period of feeling less than great (unusual tiredness, lower libido) but I didn’t associate it with the niacin until I saw the timely (for me) link below about niacin and methylation issues. In all the reading I had done about niacin I had never seen mention of his, but when I searched for “niacin and methylation” a lot of confirming detail came up, so this seems like a credible concern. I stopped the niacin and started TMG per the video, and I now feel spectacular.
https://chrismasterjohnphd.com/2018/07/26/careful-niacin-nicotinamide-riboside/
Different people have different methylation patterns, so this may not apply to everyone or even most people, but it is a good concern to be aware of. I may try to restart the niacin in concert with TMG per the video, however I will be on the look-out for any signs of negative symptoms. I am very interested in any studies that actually show an improvement in actual cardiovascular events due to niacin as opposed to studies looking at lipid markers. There seems to be conflicting evidence as to whether niacin actually has a conclusive benefit or whether it (like statins) move blood panel numbers around with no significant benefit and the potential for harm, and credible doctors who once used it (specifically Dr. Davis) seem to have backed away from it.
https://chrismasterjohnphd.com/2018/07/26/careful-niacin-nicotinamide-riboside/
Different people have different methylation patterns, so this may not apply to everyone or even most people, but it is a good concern to be aware of. I may try to restart the niacin in concert with TMG per the video, however I will be on the look-out for any signs of negative symptoms. I am very interested in any studies that actually show an improvement in actual cardiovascular events due to niacin as opposed to studies looking at lipid markers. There seems to be conflicting evidence as to whether niacin actually has a conclusive benefit or whether it (like statins) move blood panel numbers around with no significant benefit and the potential for harm, and credible doctors who once used it (specifically Dr. Davis) seem to have backed away from it.
Last edited:
