Help - 4 weeks on TRT + Nipple Pain / Estradiol = 20 pg/ml ???

Drug350

Member
So I just got my 5th weekly shot, 100 MG's Testosterone Cypionate. My nipples starting hurting about the 3rd week, and continue to hurt. I bumped into a wall the other day hitting my chest /nipple and it fu_kin hurt like hell !!!! If I touch my nipples, pushing up and down, they hurt or push directly on them they hurt bad. They also look bigger (nipples). I had 3 blood tests done prior to starting TRT, and my numbers looked like this:

Testosterone = 169 NGDL
Free Testosterone = 3.1 NGDL
Bioavailable Testosterone = 72.6 NGDL
SHBG =34 nmol/L
TSH = 2.64 uiU/ml
Prolactin = 14.6 ng/ml
Estradiol = 21 pg/ml
LH = 3 mlU/ml
FSH = 4 mlU/ml
PSA = .5 ng/ml

I just had blood work ran today and I expected my Estradiol to be significantly higher, but it wasn't. It even dropped from 21 pg/ml before, to 20 pg/ml now. I don't believe she ordered a Prolactin test again, although I'm thinking that could very well be the reason my nipples are hurting. I do have some gyno from past cycles I've done when I was younger and I'm looking into gyno surgery so I can have these glands removed and never have to worry about these problems again. In the meantime, would it be worth taking a small dose of anastrozole or tiny dose of letro to see if there's any changes ??? Honestly, my estrogen at 20 I though was almost perfect, perhaps even on the lower side for being on TRT. I wouldn't think I'd want it much lower than 20 pg/ml. Thank you in advance for any and all suggestions.
 
I just had blood work ran today and I expected my Estradiol to be significantly higher
A lot of guys think estrogen is the boogie man, that it solely causes nipple pain and tenderness. I have nipple pain, burning in the weeks leading up to a steady state and these issues went away after 6 weeks.

Your hormone levels are in flux, this is what’s causing these symptoms and the nipple pain may very well disappear after 6 weeks.
 
A lot of guys think estrogen is the boogie man, that it solely causes nipple pain and tenderness. I have nipple pain, burning in the weeks leading up to a steady state and these issues went away after 6 weeks.

Your hormone levels are in flux, this is what’s causing these symptoms and the nipple pain may very well disappear after 6 weeks.
OK. Awesome. Thank you. I just got my testosterone numbers back. I shoot 1/2 CC, so 100 MG's on Tuesday. I had my bloods drawn a week later, Tuesday night, so these were my numbers a week from last shot, a month in. My testosterone numbers have really shot up. I realize the ranges below are probably much lower than most TRT Clinics, but this is through my Urologist and it's what they go by. These numbers are telling me that I must be above 1000, maybe quite a bit, the first few days after my shot. I was actually surprised to see these numbers this high a full week later. I'm thinking my estrogen could be much higher the first few days, than slowly dropping to 20 pgml a week later. I'm going to split the dose, and go every 3 days instead of 1 large dose once a week and see if the nipple pain goes away.

Total = 610 NGDL (normal range 200 - 745)
Free = 11.8 NGDL (normal range 3.1 - 12.8)
Bioavailable = 276.5 NGDL (normal range 71.7 - 300)
SHBG = 40.00 nmol (normal range 13 - 74 nmol)
 
What other medications are you taking? Any growth hormone or peptides?

Nipple pain has been discussed several times.
No. Absolutely NOTHING. I haven't done any gear in 2+ years. No peptides whatsoever. The only drugs I'm on are TRT and daily Cialis. I'd love to find an online clinic that would supply GH, like 1 - 2 IU's daily, weekend's off, would be great. Absolutely zero chance my GP or Urologist would write GH.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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