HCG + Test and azoospermia

RapperT

New Member
Hi all,

I am a 33 year old male with azoospermia not attributed to trt. It was most likely caused by years of alcohol abuse (6 + years sober now).

My test levels were under 100 and LH, FSH both under 1. My urologist tried me on clomid for awhile and it actually bought my T down to 10 with no effect on LH and FSH. I had an MRI of pituitary which came back negative.

My question is, do you think I have any hope of producing sperm by implementing some sort of hcg/hmg protocol either with or without my trt? I see a lot of info about hcg PRESERVING fertility when run concurrently to TRT, but not much about its effects if men who were azoo prior to starting trt.

I am using the bare minimum of test right now to have some sort of quality of life (last bloods came back at 495..one pump of fortesta to each thigh daily). I would like to continue if possible but am willing to stop if necessary.

all other blood levels were in range...had full hormone panel (except estradiol which is weird...will ask doc tomorrow).

Any help is appreciated.

Rich
 
Rich:

Have you tried testosterone replacement with 2-3 shots a week of HCG (500 IU)? It would be interested if you would respond like the men in Dr Lipshultz' study.

https://www.excelmale.com/forum/sho...e-Testicular-Shrinkage-and-Preserve-Fertility

If that does not work, then HCG/HMG may be the way to go. HMB is very expensive, though.

Here is a good paper on the use of HMG

Pulsatile GnRH or human chorionic gonadotropin/human
menopausal gonadotropin as effective treatment for men with
hypogonadotropic hypogonadism: a review of 42 cases
 
Thanks for the reply and the links Nelson....I will read them right now. I am going to ask my doc about that protocol tomorrow. I think he will be willing to give it a try. How long do you suggest i wait before my next semen analysis? I read somewhere that it can take up to 6 months for sperm to produce.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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