Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

Yes they do.

But you know how much tadalafil is in one pill - 20mg.

So, if you want 5mg, that's a quarter of that.

Whatever 20mg pill you have, you weigh one. Mine are about 0.348 grams.

Then for a quarter, divide by 4 - with a calculator (most PCs have one in "Accessories" or you can even do a calculation by typing it in Google.com).

In my case, that is 0.087 grams for a quarter of a pill (5gm of tadalafil). So, if I split the weird shaped pills and the pieces are 0.12 and 0.05 grams, I know they are way too big and too small. What I am probably going to do is crush those and weigh out 0.087 gram amounts of the crushed pills on the scale.

The scale (linked in the previous post) actually weights that finely - it is made for stuff like gems where tiny fractions of weight can make a difference.

So, the first step is always to weigh one whole pill, then you know how much 20mg weighs.

Is that scale good enough for "compounding" your own low dose anastrozole? I've read about guys who grind up a 1mg anastrozole, mix it with a binder like calcium carbonate or something similar, and then dividing it up to the dose that they want.

 

Is that scale good enough for "compounding" your own low dose anastrozole? I've read about guys who grind up a 1mg anastrozole, mix it with a binder like calcium carbonate or something similar, and then dividing it up to the dose that they want.

You should read the customer comments on the scale, they can give you some idea of the accuracy.

I suppose it would depend on how much binder - i.e. how much total weight.

The scale is about $25, and apparently the next level up of accuracy is $100-$200.

And it also depends on how critical it is for it to be accurate. In the case of tadalafil, if you end up with 4.5mg instead of 5mg, it is not a big deal.

BTW, with the scale in the link - follow the setup directions that are included. It's easy, but it is important to use the included two weights to calibrate it before your first use.

 

Couldn't you disolve it in liquid and then just use a dropper to dispense it in the amount you want?

 

Couldn't you disolve it in liquid and then just use a dropper to dispense it in the amount you want?

A web search shows that tadalafil is insoluble in water, and poorly dissolves in any liquid. (This is why the "Liquid Cia" users describe having to shake the product every time. That aside from the fact that I am not interested in the product because they won't disclose what is in it, aside from the "cia", and even then you don't know which tweaker chemist made it in his trailer.)

Crushing a pill in a pill crusher creates a powder that you can potion out equally well using the scale.

 

No doubt cutting or crushing will work, I was just thinking easier dosing and several tablets won't disolve in water but I was thinking vodka since it will work for some. It's definitely bad when you don't know the extra ingredients in a product, good luck with your search.

 

I use "Liquid Cia" and it works...wonderfully I might add.

As far as not "knowing" what's in it...think about that same thing every time you purchase your vitamins, or any supplement for that matter, that is not regulated...you have no idea where it was made and what you are ingesting.

 

I use "Liquid Cia" and it works...wonderfully I might add.

As far as not "knowing" what's in it...think about that same thing every time you purchase your vitamins, or any supplement for that matter, that is not regulated...you have no idea where it was made and what you are ingesting.

I don't doubt that "Liquid Cia" works - otherwise they wouldn't get any repeat orders.

However, if I am ingesting something daily, I would rather have some indication that it does not have heavy metals or other contaminants.

The Tadacip product from Cipla is manufactured in relatively high level facilities:

http://www.cipla.com/Home/Facilities/Plants.aspx?mid=1291

 

I assembled all ingredients, except the Cialis which is on its way, I have been taking another form of a N.O. stack for almost 4 years.

I feel like my body is on high octane fuel. Im an energetic man anyway, OMG, this is possibly a small side effect for me? I don't have a recreational drug history but can only imagine that this is what it might be like to take an nice upper <G>.

Anyone else have a similar reaction ?
Duane

 

Hi Gene,

Great thread! Glad I found it!

Doc already has me on Doxazosin but 2mg which I take at night. He also has me on 5mg of daily Cialis.
Horny Goat Weed did nothing for me but I think the Pycnogenol and L-Arginine L-Citrulline Complex would.

Any ideas about dropping the Icariin and modifying your stack? Total dosages are right, its just the timing and dropping the Icariin.

I workout regularly and play ice hockey. So for someone my age, I'm 50, I'm in good shape. I'm just not a kid anymore!

 

I'm not sure if this question has been asked but can I buy these products in bulk (minus the pharmaceuticals, I will take them separately) and then add them to juice and sip it throughout the day? I have done this with other supplements and I find it much more convenient and cheaper.

 

I'm not sure if this question has been asked but can I buy these products in bulk (minus the pharmaceuticals) and then add them to juice and sip it throughout the day? I have done this with other supplements and I find it much more convenient and cheaper.

I really don't think that would work. Especially on the prescription drug side of the stack. Those pills are going to be tiny. I also think its cost prohibitive but maybe someone else can chime in?

I can say I use a modified version of this (less l-Arginine and less L-Citrulline but still as a complex) I feel fantastic and it works!

 

I really don't think that would work. Especially on the prescription drug side of the stack. Those pills are going to be tiny. I also think its cost prohibitive but maybe someone else can chime in?

I can say I use a modified version of this (less l-Arginine and less L-Citrulline but still as a complex) I feel fantastic and it works!

Sorry, I should have stated my question more clearly. I meant elimination the prescription drugs entirely from my "drink" and taking them separately. I'll edit my post if possible to clear that up.

 

I can say I use a modified version of this (less l-Arginine and less L-Citrulline but still as a complex) I feel fantastic and it works!

L-Citrulline is probably the most important part of the stack.
L-Arginine is only helpful a half hour before a workout (of whatever kind ), because it dissipates quickly.

L-Citrulline is an amino acid. It is turned into L-arginine in the kidneys after supplementation, which means L-citrulline supplementation is a more effective method of increasing L-arginine levels in the body than L-arginine supplementation.

For more details.see:

http://examine.com/supplements/Citrulline/

 

By the way, amazingly enough, you can make the stack more delicious by adding one-third of a Lindt or other brand 85% Cocoa Dark Chocolate bar daily - more studies have been done demonstrating blood flow improvement from Cocoa flavonols than any other supplement. See:

http://examine.com/supplements/Cocoa+Extract/

( That's something like 75 cents a day extra expense, OR you can substitute it for the Pycnogenol, since the mechanism of action is probably similar. )

 

L-Citrulline is probably the most important part of the stack.
L-Arginine is only helpful a half hour before a workout (of whatever kind ), because it dissipates quickly.



For more details.see:

http://examine.com/supplements/Citrulline/

Can you recommend a brand/type of Citrulline and daily dosage?

 

Can you recommend a brand/type of Citrulline and daily dosage?

They talk about dosages in the Examine.com link, and Gene has suggestions in the first post of the thread. (In the Examine.com articles, note that they will have a lot of technical details, but they put a Summary at the top, along with "How to Take" and "Editors Thoughts", which are all relatively non-technical.)

The article mentions that Citrulline Malate has less Citrulline than "Free Form", so just get the latter (which tastes neutral, while the Malate tastes bitter).

In terms of brands, just read customer reviews on Amazon.com or whatever site you use to buy supplements. Generally the amino acids are not hard to make, so you are looking for just the usual supplement supplier qualities of cleanliness, reliability, etc.

 

Is it always best to take these on an empty stomach at each step throughout the day?

 

Is it always best to take these on an empty stomach at each step throughout the day?

Yes, amino acids are best taken on empty stomach.

Takes about 20 minutes for food to leave your stomach after you eat so 30 mins you should be good to go!

 

Hey gene have you ever ordered Caber from either of these sites over seas and if so did it work and what was the name it goes by?

 

I started Gene's stacker but have not received my Tadalafil from Securetabs and Doxazosin. Expecting them as soon as possible meaning couple weeks most likely.
I did have two 10 mgs of Tadalafil and used those once a night as per Gene's suggestion if you don't have 5 mgs twice a day. Nothing the first day but woke up last night with about 3/4 wood. Not sure I can attribute that to the Tadalafil or the other ingredients but I hope once I do have the entire list good things happen. At the gym I can't honestly say I have seen a great difference but I am not one to spend more than an hour 5-6 days a week there. I do interval training, weights but not a lot and stretching.
Will report the results once I am on the full regiment of Gene's stacked ingredients.