Gene's Nitric Oxide Stack

Many have used this stack for massive hard pumps in the gym, significant vascularity and excellent erectile function not discounting the health benefits. If you're looking for any of these benefits and more...give it a try!

Nitric Oxide Stack
Bed Time
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)


Morning
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)

Afternoon
5 mg of Tadalafil (Cialis)
3000 mg of L-Arginine
1500 mg of L-Citrulline
50 mg of Pycnogenol
150 mg of Icariin (Horny Goat Weed)
1 mg of Doxazosin (Alpha Blocker)

More Than a Muscle Pump: The Surprising Science of the Nitric Oxide Stack​

In the biohacking world, we often chase complex peptides or experimental compounds, but we frequently overlook the most fundamental currency of life: blood flow. In the quest for longevity, systemic vascular efficiency is the baseline upon which all other health markers are built. As we age, our ability to maintain vasodilatory capacity diminishes, impacting everything from cognitive sharpness to metabolic health. "Gene’s Nitric Oxide Stack," a protocol born and refined within the ExcelMale community, has emerged as a definitive solution for men seeking to optimize this system. This isn't just a gym supplement routine; it is a sophisticated approach to anti-aging that leverages amino acids and targeted pharmaceutical interventions to restore the body’s most vital delivery mechanism.

Beyond the Mirror: The Science of the Sustained Pump​

For the average gym-goer, the "pump" is a transient aesthetic goal—a fleeting moment of muscle fullness. However, for a longevity specialist, a "harder pump" and increased vascularity are indicators of high-functioning endothelial health. The Nitric Oxide Stack is engineered to produce a state of vasodilation that doesn't simply vanish when you rack the weights.

By optimizing the nitric oxide signaling pathway, this protocol facilitates a sustained pump that carries through your daily life. This is a critical distinction: the visual vascularity is a proxy for your body’s ability to keep its "pipes" open. When you maintain that fullness hours after a workout, you are essentially providing proof of concept that your circulatory system is operating at peak efficiency, ensuring constant nutrient delivery to peripheral tissues.

The Foundation of Performance: Hard Science for Sexual Vitality​

One of the most immediate benefits of systemic vasodilation is the restoration of sexual function. From a clinical perspective, erection quality is often the "canary in the coal mine" for cardiovascular health. Because the Nitric Oxide Stack focuses on the root physiological requirements of performance—blood flow and retention—it provides a robust alternative to temporary fixes.

A Serious Solution for Erection Quality and Duration

This stack addresses both the quality and the duration of erections with clinical precision. For men navigating the aging process, this is not a matter of vanity, but of maintaining vital physiological function. By ensuring the vascular system can respond effectively to neurological signals, the protocol allows for a level of performance that many mistakenly believe is lost to time.

The Ultimate Nootropic: Future-Proofing the Neocortex​

Perhaps the most compelling argument for nitric oxide optimization is the "bodybuilder to brain health" pipeline. While most men start this stack for its physical benefits, they are unknowingly deploying a powerful shield against age-related cognitive decline. As we age, the micro-vasculature within the brain tends to narrow and tighten, a process that starves the brain of oxygen and is a primary driver of age-related dementia.

The stack acts as a nootropic by ensuring that the brain's smallest vessels remain dilated and resilient. This ensures that the neocortex and other critical regions receive a constant supply of the nutrients required for cognitive longevity. As the source material highlights:

"by increasing nitric oxide and getting that vascular dilation we're getting oxygen blood and nutrients in the areas of the brain that can provide us with a great anti-aging benefit in terms of neurological health."

The irony is profound: a protocol often associated with the bicep curl may actually be one of your most effective tools for protecting your mind.

Systemic Management: Blood Pressure and Prostate Function​

The benefits of the stack extend into the deeper mechanics of men’s health, specifically regarding the relaxation of smooth muscle tissue. This is particularly relevant for Benign Prostate Hyperplasia (BPH) and blood pressure management. Nitric oxide serves as a signal for these tissues to relax, directly easing the "inability to ease the problems" that typically characterize age-related prostate issues.

The secondary physiological advantages of this systemic relaxation include:

• Vascular Tension Reduction: Significant support for maintaining healthy blood pressure levels by reducing resistance within the arterial walls.
• Prostate Relief: Improvement in quality of life by relaxing the prostatic smooth muscle, easing the mechanical symptoms of BPH.
• Reduced Cardiac Load: By improving systemic flow, the heart is not required to pump against the same level of resistance, preserving cardiovascular longevity.

The Future of Your Vascular Health​

"Gene’s Nitric Oxide Stack" is far from a theoretical exercise; it is a "living protocol" backed by years of community peer-review within the ExcelMale community. The "enormously long" and widely viewed thread on ExcelMale.com serves as a testament to the real-world efficacy of this stack, offering a repository of shared experiences and optimization strategies.

This multi-front approach to anti-aging represents the best of biohacking: using fundamental biological pathways to solve complex aging problems. By focusing on the delivery system itself, we can protect our brains, our hearts, and our vitality simultaneously.

If blood flow is the delivery system for every nutrient your body needs, what happens to your longevity when you finally optimize that system?


More on Nitric Oxide in Men:

Nitric Oxide Pages

 

Here is some good info on glutamine:

http://defymedical.com/resources/health-articles/170-amino-acid-l-glutamine

From the book "Built to Survive":

Glutamine

For any loss of muscle, Judy Shabert, M.D., M.P.H., R.D., asserts that supplementing with high doses of the amino acid L-glutamine, will help reduce the catabolic process of breaking down muscle tissue,http://www.excelmale.com/#_edn1 and a recent study of wasting HIV patients by Prang showed that this might be true. (See Dr. Shabert's article in the August 1997 issue of POZ magazine.) For frank wasting, HIV(+) people are using between 12 and 36 grams per day of L-glutamine. (One tablespoon is 12 grams.) I have friends who have halted their random diarrhea and improved their lean body mass using these kinds of L-glutamine doses, and in Prang's study wasting and diarrhea and were checked by using 30 to 40 grams of glutamine per day. Glutamine too, has been shown to have a powerful effect on improving glutathione production,[ii] and glutamine improves insulin sensitivity.[iii] [iv]

---

http://www.excelmale.com/#_ednref1 Hickson, RC, et al. Glutamine prevents down regulation of myosin heavy chain synthesis and muscle atrophy from glucocorticoids. Am J Physiol [Endo Metab] (1995) 269(31):E730-E734.

[ii] Hong, RW, et al. Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg (1992) 215(2):114-119.

[iii] Opara, EC, et al. L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice. J Nutr (1996) 126(1):273-279.

[iv] Borel, MJ, et al. Parenteral glutamine infusion alters insulin-mediated glucose metabolism. J Parenter Enteral Nutr (1998) 22(5):280-285.

 

Nelson Vergel, in your opinion 10mg of daily Cialis, is that correct? At mysecuretab.com they only have the 20mg. Cialis. So I belive I can cut it in half by Genes advice. Let me know, please and thank you in advance.

 

Nelson Vergel, in your opinion 10mg of daily Cialis, is that correct? At mysecuretab.com they only have the 20mg. Cialis. So I belive I can cut it in half by Genes advice. Let me know, please and thank you in advance.

Just cut the 20 mg pill into two 10 mg and take 1 before bed. With a 16 hour half life you will get about the same subjective effects as two 5 mg every 12 hours.

 

What Gene said above.

 

Does anyone know if doxazosin lowers testosterone? This study, at least to me, suggests it does (at least in rats)

http://www.ncbi.nlm.nih.gov/m/pubmed/17573849/?i=11&from=doxazosin testosterone

 

Does anyone know if doxazosin lowers testosterone? This study, at least to me, suggests it does (at least in rats)

http://www.ncbi.nlm.nih.gov/m/pubmed/17573849/?i=11&from=doxazosin testosterone

Yes, it does say that serum testosterone levels were lowered in lab rats.

Human men are not not lab rats and if there were a history of lowered androgen levels in man prescribed Doxazosin there would be reference to it in the formulary by now as this drug has been around for many many years.

This is the first time I have ever seen any study of the such suggesting that an alpha blocker can reduce serum testosterone levels.

If it concerns you, in light of no human trials, don't use it as part of the stack.

There are many many environmental agents we come into contact with everyday that lower androgen levels and increase estrogen levels so you may be just as concerned about those as well.

If you are on a TRT protocol than you should have no concern anyways as you are already HPTA suppressed and using exogenous testosterone anyway.

 

Yes, it does say that serum testosterone levels were lowered in lab rats.

Human men are not not lab rats and if there were a history of lowered androgen levels in man prescribed Doxazosin there would be reference to it in the formulary by now as this drug has been around for many many years.

This is the first time I have ever seen any study of the such suggesting that an alpha blocker can reduce serum testosterone levels.

If it concerns you, in light of no human trials, don't use it as part of the stack.

There are many many environmental agents we come into contact with everyday that lower androgen levels and increase estrogen levels so you may be just as concerned about those as well.

If you are on a TRT protocol than you should have no concern anyways as you are already HPTA suppressed and using exogenous testosterone anyway.

Thanks for replying Gene. I was concerned because, as I'm not on trt I felt it could affect me (I'm currently on self administered low dose clomid though). And I didn't want to leave doxazosin out as I've found it SO effective for erections when used with cialis compared to just cialis on its own.

 

Hey Gene quick question. Over the years my testes have always pulled up but once I started TRT they have shrunk some and can quite easily full retract. But one thing I noticed that I haven't had for a long time was I was getting some sac hang. Recently I stopped taking L-arginine and L-citruline partially due to cost and there is some negative press out there. After stopping, the sac was shrinking up bad. Well I recently saw this post and I thought I would try again. Before I was only taking 1000mg of each once a day. I wanted to try more but didn't want to go as high as you so I am doing 2000mg of L-arginine twice a day and 1000 mg of l-citruline twice a day. It's only been 3 days and I have already noticed it dropping. I thought it took a while. Also any good recommendations for low cost good quality Arginine and citruline?

 

Not sure if this question has been asked before, but what is the proper dosage for Yohimbine? It was recommended in a another thread on supplements, but didn't indicate the proper dosage and timing. Supposedly increases sensitivity?

 

Not sure if this question has been asked before, but what is the proper dosage for Yohimbine? It was recommended in a another thread on supplements, but didn't indicate the proper dosage and timing. Supposedly increases sensitivity?

Yohimbie can be used as an ED treatment but one must take this supplement with extreme caution.

It can impact the CNS in a very bad way and can cause extreme anxiety and panic attacks in some people.

I tolerate drugs very well but this stuff had me crawling up the wall...I'll never take it again.

 

Thanks, Gene, for the heads up. I certainly don't need more anxiety.

 

WebMD on Yohimbe side effects:

Yohimbe, taken by mouth, is POSSIBLY UNSAFE. Yohimbe has been linked to reports of severe side effects including irregular or rapid heart beat, kidney failure, seizure, heart attack, and others.


The primary active ingredient in yohimbe is a drug called yohimbine. This is considered a prescription drug in North America. This drug can be safely used short-term when monitored by a health professional. However, it is not appropriate for unsupervised use due to potentially serious side effects that it can cause.


Children should not take yohimbe. It is POSSIBLY UNSAFE for children because children appear to be extra sensitive to the harmful effects of yohimbe.


When taken by mouth in typical doses, yohimbe and the ingredient yohimbine can cause stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting.

Taking high doses can also cause other severe problems, including difficulty breathing, paralysis, very low blood pressure, heart problems, and death. After taking a one-day dose of yohimbine, one person reported an allergic reaction involving fever; chills; listlessness; itchy, scaly skin; progressive kidney failure; and symptoms that looked like the auto-immune disease called lupus.


Special Precautions & Warnings:
Pregnancy or breast-feeding: Yohimbe is LIKELY UNSAFE. Yohimbe might affect the uterus and endanger the pregnancy. It might also poison the unborn child. Don't take yohimbe if you are pregnant or breast-feeding.


Schizophrenia: Use yohimbe with caution. The yohimbine in yohimbe might make people with schizophrenia psychotic.


Prostate problems: Use yohimbe with caution. Yohimbe might make the symptoms of BPH (benign prostatic hyperplasia) worse.


Post-traumatic stress disorder (PTSD): Don't use yohimbe. There is a report that four individuals with PTSD suffered worse symptoms after using yohimbe.


Liver disease: Don't use yohimbe. Liver disease might change the way the body processes yohimbe.


Kidney disease: Don't use yohimbe. There is a concern that yohimbine might slow or stop the flow of urine.


High blood pressure or low blood pressure: Don't use yohimbe. Small amounts of yohimbine can increase blood pressure. Large amounts can cause dangerously low pressure.


Chest pain or heart disease: Don't use yohimbe. Yohimbine can seriously harm the heart.


Anxiety: Don't use yohimbe. Yohimbine might make anxiety worse.

Depression: Don't use yohimbe. Yohimbine might bring out manic-like symptoms in people with bipolar depression or suicidal tendencies in individuals with depression.


Diabetes: Don't use yohimbe. Yohimbe might interfere with insulin and other medications used for diabetes and cause low blood sugar.

 

Diabetes: Don’t use yohimbe. Yohimbe might interfere with insulin and other medications used for diabetes and cause low blood sugar.

This is really good to know! I will have to check on Metformin and the interaction.

 

Men , What form do you take ? Pill or Powder on Arginine and Citrulline ? Thanks

 

I found powder form to be less expensive and doesn't have a bad taste. So on the stack whatever I found in powder form that's the one. It work perfect. Try it. Your pocket will thank you.

 

Seems mysecuretabs.com has been down for a few days. Is All Day Chemist good to use for generic Cialis?

 

Seems mysecuretabs.com has been down for a few days. Is All Day Chemist good to use for generic Cialis?

mysecuretabs.net New URL.

 

mysecuretabs.net New URL.

Is this the cheapest place to buy Cialis with or without a script ?

 

Is this the cheapest place to buy Cialis with or without a script ?

Peptide research sites are cheap and reliable.

Just Google Liquid Cia and you have your choice.

What's nice about the Peptide sites is their Cialis is in a liquid form. Just make sure to shake the vial really good as the formula separates.

Just put your dose under your tongue and it gets into the bloodstream right quick

 

Peptide research sites are cheap and reliable.

Just Google Liquid Cia and you have your choice.

What's nice about the Peptide sites is their Cialis is in a liquid form. Just make sure to shake the vial really good as the formula separates.

Just put your dose under your tongue and it gets into the bloodstream right quick

Wow information overload when i Google Liquid Cia to much info to many companies to choice from and no idea which ones are legit

Where do you buy from? Could you point me in the right direction to save some bucks?