From enclomiphene to TRT cream - where do I stand?

[mcs]

Hey all,

I’ve been on topical TRT compounded cream (100 mg/day) for 52d now. No prior exogenous T before this. 50mg twice daily (AM/PM), rotating between behind knees, deltoids, and inner thighs. Chose to avoid transscrotal application as I didn't want to spike DHT/E2.

I was on enclomiphene at 25 mg/day for the last 2y up until the last 10d. Although it did raise TT into the mid-600s, it didn't move the needle much on FT. Recently added TRT to push further anabolic support.

Current Stats:

• Age: 65​

• Height: 5'7"​

• Weight: 160 lbs​

• 11-12% bf (DEXA)​

• ~132 lbs lean mass​

• Training 5–6x/week, eating high protein (~200g/day)​

• BP stable at 120–125/70​

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Subjective effects:

• Noticeably more morning wood and some libido increase​

• No signs of DHT-related issues​

• No water retention or high E2 symptoms​

• No mood issues or fatigue​

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Symptoms (may not be related?):
• Increased joint pain in prone sites of tendinopathy (shoulders, elbows)

Concerns / Questions:

• FSH/LH not fully suppressed — perhaps from enclomiphene alongside TRT?​

• SHBG hasn’t dropped, even though I assumed it might on exogenous T​

• HDL dropped — likely from TRT?​

• Ferritin is higher than usual — may be related to diet (heme iron supps) but keeping an eye on it​

• IL-6, hsCRP and cystatin C (eGFR) are elevated (separate issue I’m tracking — possible LPS exposure months back)​

• Have been on peptide regimen (BPC-157/TB500/ipamorelin/frag//cjc/tesamorelin/AOD/IGF1-LR3; split dosing; cycle off 2d/week)​

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Attached are most recent labs for review — curious to hear your feedback, especially on:

• Whether my current dose is optimal or needs tweaking​

• Any flags in hematocrit, lipids, or hormone feedback​

• Any risk in discontinuing enclo + TRT combo long-term
(FT3 is elevated due to peak serum level from dosing 2h prior to draw)​

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Thanks in advance.