sensitivity issue can't solve

[42HRT]

Same here, but using compounds like THC, nicotine, Whatever it may be is altering the OP's regular state. Depending how often he is using normal dopamine could be blunted. Selegiline, did give me a good libido boost when I tried it, but after awhile it made me irritable.

I ordered and have selegiline. However, I am hesitant to take it since its really for parkinsons. So I tried wellbutrin first

 

[42HRT]

our age. That is an important factor.

I battled this for years myself. TRT can alter neurotransmitter balance both in a positive and negative way. To echo some opinions on this thread, your testosterone dose is double what it should be. As Phil mentioned above, before trying anything else, try a single dose per week at 110 mg for a few weeks and monitor the changes between peak and trough.

It would also be a good idea to test DHT.

Wellbutrin is a great drug for some, but not for everyone. It mainly affects norepinephrine and not dopamine. It can increase anxiety in a lot of people. Anxiety is a libido and sexual function killer. Maybe that is why THC helps?

You didn't mention your age. That is an important factor.

IMHO... HCG is an absolute must for those on TRT.

The cure for me was selegiline. The dosage and frequency are based on age. There are other options as well.

If anxiety isn't a problem, try Yohimbine HCL. Just don't take it while also taking Wellbutrin!

Topical DHT applied to the penis or perinium works like magic. If you don't have a source for DHT, use T Gel.

This doesn't have to be a forever thing, but it will take some time and some experimentation to get you back in the saddle.

Im 44. I do have selegiline on hand. But I was hesitant to take it since its for parkinsons
So i wanted to try Wellbutrin first and definitely won't be taking both at the same time. What's your dosage on selegiline and frequency. How long have you been on it?

 

[42HRT]

Anyone know where to get vyvanse? or tried it?

 

[Cataceous]

Can you give me some more information on what drugs you took to do this?
Or links? I haven't heard of either.
@Cataceous

My approach is overly complex and impractical for most; it involves multiple daily injections. It's much simpler to first try significant dose reductions, and if no luck there then try switching to a short-acting form of testosterone, as these resolve hypogonadism with less hormonal chaos than conventional TRT. Your current TRT dose is likely still on the order of double what your healthy natural production would be, which is around 5-7 mg of testosterone daily. This corresponds to 50-70 mg of testosterone cypionate weekly. Excessive testosterone can have negative effects on 20-30+ other hormones and neurotransmitters. My discussion of two of the most directly affected hormones:

C

Thread 'Is GnRH suppression hurting us?'

Jan 26, 2020

Admittedly the last thing we need is some other nebulous danger to worry about that may not even exist. Read on at your peril.

TL;DR: Testosterone replacement therapy suppresses the production of GnRH. Receptors for GnRH are found in places besides the pituitary. One animal model suggests GnRH may have health benefits independent of its stimulation of LH and FSH production.

The background: Gonadotropin-releasing hormone, or GnRH, is the signal the hypothalamus uses to tell the pituitary gland to secrete luteinizing hormone and follicle stimulating hormone. Luteinizing hormone (LH)...

• Cataceous
• gnrh hpta suppression
• Replies: 63
• Forum: Testosterone Side Effect Management

• 

C

Thread 'Kisspeptin suppression under TRT: Can it affect mood and libido?'

Jul 19, 2020

TD;LR: Kisspeptin may affect how we act and feel. It seems plausible that a TRT-induced reduction in this hormone is a problem for some men.

I’d previously asked if suppression of GnRH by TRT is a problem. The literature at least hints that it is possible. The situation with kisspeptin may be similar. The kisspeptin hormone sits near the top of the male sex hormone cascade. It helps stimulate GnRH production, which in turn leads to LH and FSH, which leads to testosterone and then estradiol. Testosterone and estradiol then provide negative feedback for kisspeptin production in the...

• Cataceous
• kisspeptin libido mood trt
• Replies: 27
• Forum: When TRT Is Not Enough (ED, Libido, & More)

• 

In any case, if you can switch to short-acting TRT then your hormones operate closer to normal, reducing the risk of side effects. Short-acting testosterone includes nasal gels, buccal troches and possibly certain oral formulations. The former two are the best proven, but are less convenient. A trial could at least establish whether the approach is helpful to you. These forms of TRT are simpler than trying to directly replace the suppressed GnRH with gonadorelin and the suppressed kisppeptin with kisspeptin-10.

Read some other accounts of the misery caused by excessive TRT dosing:

C

Post in thread 'Answering some questions, new to forum. Much appreciated!'

Feb 6, 2023

Adding to what @Systemlord said, you're currently on 200 mg of testosterone cypionate per week. This averages to 20 mg of testosterone per day, which is about three times the average amount that a healthy young man makes naturally. Would you consider this advisable if it were any other hormone? High levels of testosterone can negatively affect more than 20 other hormones.

Unfortunately it's a very common experience, with many doctors succumbing to the more-is-better mentality. Ideally you should have been started on 75 mg TC split into 2-3 doses per week. You go up or down from...

• Cataceous

• 

Especially this one:

S

Post in thread 'Numb Penis, Anorgasmia during Sex, Low Cortisol, High Prolactin on TRT'

Aug 7, 2022

I experienced this "dead wood" penis insensitivity on and off for a long time while on dosages around 100 mgs per week of T. When I lowered the dose down to 60-70 mgs, sexual sensitivity improved considerably. Erectile function is also more responsive and reliable.
At first I felt the effects of low T for some time. Over a period of months this corrected itself and I feel much better all round.
I had tried this before, but given the "low t' effect, I resumed the higher doses thinking, my dose was too low. This time I persisted and gave it more time for my body to adjust.
How important this...

• Simbarn

• 

 

[42HRT]

My approach is overly complex and impractical for most; it involves multiple daily injections. It's much simpler to first try significant dose reductions, and if no luck there then try switching to a short-acting form of testosterone, as these resolve hypogonadism with less hormonal chaos than conventional TRT. Your current TRT dose is likely still on the order of double what your healthy natural production would be, which is around 5-7 mg of testosterone daily. This corresponds to 50-70 mg of testosterone cypionate weekly. Excessive testosterone can have negative effects on 20-30+ other hormones and neurotransmitters. My discussion of two of the most directly affected hormones:

C

Thread 'Is GnRH suppression hurting us?'

Jan 26, 2020

Admittedly the last thing we need is some other nebulous danger to worry about that may not even exist. Read on at your peril.

TL;DR: Testosterone replacement therapy suppresses the production of GnRH. Receptors for GnRH are found in places besides the pituitary. One animal model suggests GnRH may have health benefits independent of its stimulation of LH and FSH production.

The background: Gonadotropin-releasing hormone, or GnRH, is the signal the hypothalamus uses to tell the pituitary gland to secrete luteinizing hormone and follicle stimulating hormone. Luteinizing hormone (LH)...

• Cataceous
• gnrh hpta suppression
• Replies: 63
• Forum: Testosterone Side Effect Management

• 

C

Thread 'Kisspeptin suppression under TRT: Can it affect mood and libido?'

Jul 19, 2020

TD;LR: Kisspeptin may affect how we act and feel. It seems plausible that a TRT-induced reduction in this hormone is a problem for some men.

I’d previously asked if suppression of GnRH by TRT is a problem. The literature at least hints that it is possible. The situation with kisspeptin may be similar. The kisspeptin hormone sits near the top of the male sex hormone cascade. It helps stimulate GnRH production, which in turn leads to LH and FSH, which leads to testosterone and then estradiol. Testosterone and estradiol then provide negative feedback for kisspeptin production in the...

• Cataceous
• kisspeptin libido mood trt
• Replies: 27
• Forum: When TRT Is Not Enough (ED, Libido, & More)

• 

In any case, if you can switch to short-acting TRT then your hormones operate closer to normal, reducing the risk of side effects. Short-acting testosterone includes nasal gels, buccal troches and possibly certain oral formulations. The former two are the best proven, but are less convenient. A trial could at least establish whether the approach is helpful to you. These forms of TRT are simpler than trying to directly replace the suppressed GnRH with gonadorelin and the suppressed kisppeptin with kisspeptin-10.

Read some other accounts of the misery caused by excessive TRT dosing:

C

Post in thread 'Answering some questions, new to forum. Much appreciated!'

Feb 6, 2023

Adding to what @Systemlord said, you're currently on 200 mg of testosterone cypionate per week. This averages to 20 mg of testosterone per day, which is about three times the average amount that a healthy young man makes naturally. Would you consider this advisable if it were any other hormone? High levels of testosterone can negatively affect more than 20 other hormones.

Unfortunately it's a very common experience, with many doctors succumbing to the more-is-better mentality. Ideally you should have been started on 75 mg TC split into 2-3 doses per week. You go up or down from...

• Cataceous

• 

Especially this one:

S

Post in thread 'Numb Penis, Anorgasmia during Sex, Low Cortisol, High Prolactin on TRT'

Aug 7, 2022

I experienced this "dead wood" penis insensitivity on and off for a long time while on dosages around 100 mgs per week of T. When I lowered the dose down to 60-70 mgs, sexual sensitivity improved considerably. Erectile function is also more responsive and reliable.
At first I felt the effects of low T for some time. Over a period of months this corrected itself and I feel much better all round.
I had tried this before, but given the "low t' effect, I resumed the higher doses thinking, my dose was too low. This time I persisted and gave it more time for my body to adjust.
How important this...

• Simbarn

• 

I appreciate that.
But that begs the question.
I'm on 110mg of cyp a week right now.
Putting my total at trough around 700-750, and my free T at the upper end of the range.
If I half my dose. What's the point of being on TRT?
Most that get on T, are looking to get to the upper end of the normal range.
I was making between 200-300 total T, before TRT. Why would I half the dose to go down there again?
Maybe I should just come off and see if I can get my low natural going again.
If i half my dose. I'm sure my total T will drop below 500 or so.

 

[Cataceous]

...
I'm on 110mg of cyp a week right now.
Putting my total at trough around 700-750, and my free T at the upper end of the range.
If I half my dose. What's the point of being on TRT?

The point of being on TRT is to treat hypogonadism and thereby improve overall health. If you had started with above-borderline natural free testosterone then most likely there would have been no point in being on TRT. The high-dose apologists may point to some rare conditions where functional hypogonadism exists in spite of seemingly normal testosterone levels. However, these are so uncommon that I don't think I've encountered a single documented case in the forums.

In any case, because you were hypogonadal originally, successful treatment does not require high-end trough testosterone and supraphysiological peaks. This is simply asking for side effects. What you're looking for is the level/variation in levels that gives you the best results overall. This is likely going to be in the physiological range—maybe in the vicinity of your healthy youthful levels—and low-and-slow dosing is a tried-and-true approach. While both dose increases and dose decreases can cause transient misleading effects, dose increases are usually more pleasant, and limiting the rate of increase minimizes spurious results.

Most that get on T, are looking to get to the upper end of the normal range.

That's because of the widespread more-is-better delusion surrounding testosterone. Sometimes it's encouraged by unscrupulous doctors, but more charitably doctors are often responding to patient demand.

If enhanced musculature and athleticism is a priority over general health then more testosterone is indeed better. But let's not pretend that such dosing is TRT.

I was making between 200-300 total T, before TRT. Why would I half the dose to go down there again?
Maybe I should just come off and see if I can get my low natural going again.
If i half my dose. I'm sure my total T will drop below 500 or so.

You're looking to have heathy levels. Naturally occurring morning total testosterone of 200-300 ng/dL implies low free testosterone and hypogonadism unless you had rock-bottom SHBG. Having a trough testosterone around 500 ng/dL on TRT is still a gigantic increase. TRT peaks on two injections per week are likely to be at least 40-50% higher than troughs, e.g. 700-800 ng/dL. Don't think for a moment that these levels are not worth trying. In my opinion, such levels should have been tried at the start, not as a fall-back after having problems with excess.