madman
Super Moderator
* Maria outlines the complex changes that occur in ageing joints, from cartilage degradation and inflammation to synovial expansion and osteophyte formation, and presents mouse models her team uses to study both naturally occurring and post-traumatic osteoarthritis.
* Her research focuses on two key ageing mechanisms—autophagy decline and cellular senescence—and how their interplay drives joint deterioration.
The burden of musculoskeletal disease
At the Longevity Forum Science Summit, Maria Kyriazi, third-year PhD researcher at the University of Oxford and Melon Scholar, delivers a compelling overview of why osteoarthritis is one of the most urgent and overlooked age-related diseases. She explains how rising lifespans without matching healthspans leave millions living for decades with pain, disability, and reduced mobility—and why understanding the biology of osteoarthritis is essential to improving healthy ageing. Maria outlines the complex changes that occur in ageing joints, from cartilage degradation and inflammation to synovial expansion and osteophyte formation, and presents mouse models her team uses to study both naturally occurring and post-traumatic osteoarthritis. Her research focuses on two key ageing mechanisms—autophagy decline and cellular senescence—and how their interplay drives joint deterioration. She also shares exciting updates from her group’s experiments aboard the International Space Station, exploring how spaceflight accelerates ageing pathways. Maria closes by highlighting the goal of her work: identifying new therapeutic strategies to protect and rejuvenate joint cells, ultimately improving life for the one in three older adults affected by osteoarthritis.
* Her research focuses on two key ageing mechanisms—autophagy decline and cellular senescence—and how their interplay drives joint deterioration.
The burden of musculoskeletal disease
At the Longevity Forum Science Summit, Maria Kyriazi, third-year PhD researcher at the University of Oxford and Melon Scholar, delivers a compelling overview of why osteoarthritis is one of the most urgent and overlooked age-related diseases. She explains how rising lifespans without matching healthspans leave millions living for decades with pain, disability, and reduced mobility—and why understanding the biology of osteoarthritis is essential to improving healthy ageing. Maria outlines the complex changes that occur in ageing joints, from cartilage degradation and inflammation to synovial expansion and osteophyte formation, and presents mouse models her team uses to study both naturally occurring and post-traumatic osteoarthritis. Her research focuses on two key ageing mechanisms—autophagy decline and cellular senescence—and how their interplay drives joint deterioration. She also shares exciting updates from her group’s experiments aboard the International Space Station, exploring how spaceflight accelerates ageing pathways. Maria closes by highlighting the goal of her work: identifying new therapeutic strategies to protect and rejuvenate joint cells, ultimately improving life for the one in three older adults affected by osteoarthritis.
