Role of SHBG in the free hormone hypothesis and the relevance of free testosterone in androgen physiology

[madman]

Thread 'Importance of free testosterone measurement in assesssing androgen disorders'

Jun 15, 2025

As usual Nelson's house is where it's at!

Importance of free testosterone measurement in assessing androgen disorders

Thursday, March 27, 2025 at 1:00 PM Eastern Daylight Time.

event.on24.com

Testosterone imbalances affect men, women, and children differently. In males, testosterone deficiency (hypogonadism) can lead to low libido, fatigue, and muscle loss, while excess may contribute to aggression and cardiovascular risks. In females, testosterone excess (hyperandrogenism), often associated with polycystic ovary syndrome (PCOS) or adrenal disorders, can cause excess hair growth, weight gain, and menstrual irregularities. In children...

• madman
• hypogonadism; free t; accuracy assays/diagnosis
• Replies: 24
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'Validating Bioavailable Testosterone by LC-MS/MS: A Clinically Accurate Alternative to Free Testosterone'

Sep 9, 2025

* Clinicians often prefer bioavailable testosterone as it more closely resembles the total bioactive testosterone in circulation when compared to free testosterone. Validation to ensure clinical accuracy of our bioavailable testosterone method modification involved a comparison of the reference interval flags between this method and verified free and total testosterone flags.


* Recently, our bioavailable testosterone assay underwent a method modification to enhance calibrator storage and quality, which required subsequent validation to confirm adequate...

• madman
• hypogonadism; free t; accuracy assays/diagnosis
• Replies: 2
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'Sex Hormone-Binding Globulin (SHBG): Biology and Biomarker'

Sep 18, 2025

Presented by Dr. Steve Winters, Emeritus Professor, Division of Endocrinology and Metabolism
Endocrinology Grand Rounds Summary

Introduction​

Sex hormone-binding globulin (SHBG) represents one of the most clinically significant biomarkers in endocrinology, with implications extending far beyond its traditional role in hormone transport. Dr. Steve Winters, a world-renowned authority on SHBG research, recently presented comprehensive insights into this protein's biology and emerging clinical applications during an endocrinology grand rounds session.

SHBG Structure and...​

• madman
• shbg; t/ft; dht/estradiol; biology
• Replies: 21
• Forum: Testosterone and Men's Health Articles

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