Estradiol levels after stopping TRT

Blizzard

New Member
I have noticed an elevated level of estrogen in blood work approximately 10 months after stopping all trt injections. There is a fair amount of data on this but would like some added input as far as potential treatment suggestions etc. In Aug 2923 they were 29.9 in November 2023 they were 89.

thx

 
I have noticed an elevated level of estrogen in blood work approximately 10 months after stopping all trt injections. There is a fair amount of data on this but would like some added input as far as potential treatment suggestions etc.
Depends on what's causing the elevation in estrogen, metabolic syndrome/obesity is the number one cause of elevated estrogen. The treatment for metabolic syndrome is TRT and more importantly, lifestyle changes.

My estrogen is elevated on TRT and I feel great because I've addressed the cause of my low-T.

Most of the symptoms men experience on TRT are the body unable to cope with high testosterone, which is why the body is down regulating your natural production in the first place.

Normal ranges for estrogen (20-40 pg/mL) were derived from men with Total T <500 and not on hormone replacement therapy.

If your Total T and Free T levels are at the top end of the ranges on TRT, you can expect estrogen to be as well.
 
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Depends on what's causing the elevation in estrogen, metabolic syndrome/obesity is the number one cause of elevated estrogen. The treatment for metabolic syndrome is TRT and more importantly, lifestyle changes.

My estrogen is elevated on TRT and I feel great because I've addressed the cause of my low-T.

Most of the symptoms men experience on TRT are the body unable to cope with high testosterone, which is why the body is down regulating your natural production in the first place.

Normal ranges for estrogen (20-40 pg/mL) were derived from men with Total T <500 and not on hormone replacement therapy.

If your Total T and Free T levels are at the top end of the ranges on TRT, you can expect estrogen to be as well.
What's the evidence for this? Seems the opposite is true. Your body will lower production of testosterone to limit the damage from high estrogen. It will happily make more testosterone if you trick it into thinking estrogen is low.
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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