Enclomiphene Depression

react5

New Member
Been on Enclomiphene (12.5 ED) about two weeks in conjunction with anestrozole (.1 3 days/wk).

In only a matter of days I fell into a serious depression that is very uncharacteristic of me. I stopped the AI thinking it might be that, but then noticed within one or two hours of taking the enclomiphene I'd drop right back into depression. Wake up feeling fine and ready to go, take the enclomiphene and feel terrible.

I don't see this reported as a side effect anywhere?
 
I noticed a difference when I switched from Clomid 25mg 4xwk to Enclomiphene 50mg 4xwk. I wasn't bad in a funk, but it was noticeable enough that I started taking the following again. I take Jarrow GABA Soothe to keep me more upbeat and it is GABA, L-Theanine and Ashwagandha. It helps me and some days I'll double up on the dose.
 
I felt off with enclomiphene, felt bad as I’m tired etc and wanted to badly get back on test plus hcg
I took the enclomiphene with my trt of 100 mg a week to try to raise my LH, which after a month it did not
I wonder if enclomiphene mixed with clomid would be better, not sure
 
Last edited:

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
0
Guests online
295
Total visitors
295

Latest posts

Back
Top