I have lower SHGB , I find I don't do well with e2 under 40pg. So I don't think we can say that low SHGB needs lower E2. I got my current e2 level into the 60s and have great libido, mood, and function. Also the fact that THC helps the OP with libido\sensitivity. This seems to point more to neurotransmitters, stress, ect.You're one of the few people Ive seen or read that seems to understand E in the presence of Low SHBG values and the effects it can have on those guys. I for one test only Estradiol, Free, when I have labs. Its logical and plausible that in a low SHBG environment where Free T is very high on a lab test, that the E is equally unbound and FREE to act on the body's systems.
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