ED/low libido even with TRT

Defy Medical TRT clinic doctor

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WhiteMale said:
You're one of the few people Ive seen or read that seems to understand E in the presence of Low SHBG values and the effects it can have on those guys. I for one test only Estradiol, Free, when I have labs. Its logical and plausible that in a low SHBG environment where Free T is very high on a lab test, that the E is equally unbound and FREE to act on the body's systems.
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I have lower SHGB , I find I don't do well with e2 under 40pg. So I don't think we can say that low SHGB needs lower E2. I got my current e2 level into the 60s and have great libido, mood, and function.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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