E2 levels for low SHBG guys (0-15)?

[Diablo666]

Hi there. Before the cream, after 5 years on injections, the only times I felt good was with:

Total T around 1,000 or higher
E2 around my SHBG level

Energy and sex drive ok, ED almost cured but not entirely, but the problem is I could manage to be like this for 3-4 days at the most, and then I lost the balance with E2, and while I tried to figure out whether my E2 was too low or too high, I would spent the next 1-2 weeks trying to adjust again and then repeat, so again not very sustainable, but before I even know about the cream that was my only way I could get back my sex drive.

Do you remember how much accutane you took, I believe I have "mild" issues at the most, I took 20mg a day for 7-8 months.

The real weird thing is that you have a hard time getting your E2 under control. Anaztrozole has a half life of 48-50 hours, but you may start noticing effects as soon as a few hours after you take it, but it can take 12-24 hrs for Estradiol to go lower. I would try increasing your AI dose until you can lower your E2 even more and see how it feel. But before that have you also tried not using AI at all? - I think the proper way to test with AIs is start without it for 6 weeks, then from there start low, wait a couple weeks, then increase the dose until you either feel better or you get your target E2 levels.

This is a link for the cream, many compounding pharmacies sell it, but you need a DR prescription. This link is from empower as an example as it is the one I use.

TESTOSTERONE CREAM | Compounding Pharmacy - Empower Pharmacy

Do you know what is your E2 levels if you have a total T around 1,000 without AI? - In my case It is around 35-40, and I can easily lower to 15-20 with 0.5mg AI a week. But maybe approach would be different for you if your E2 runs much higher, and you also have a hard time lowering, meaning you may need much higher dose of AI.

If that is the case I think cream may also work. I would recommend measuring your DHT as well, that may help prove that your T is converting much more to E2 than to DHT.

 

[Tman]

Hi All,

Can low SHBG guys comment on what is your protocol? and Whether it works successfully for libido and energy? -

From what I have read and in my personal case, when E2 is low, mirroring SHBG values, it is like the sweet spot, and rationale is that the low SHBG makes too much of free E2 in the body, so that is why we don't need as much as most other people.

However, I think I have seen a few cases of guys reporting they feel good at 25-30 E2 even with low SHBG. Wondering what could be the cause.

Also, have Test Cream worked in your case if you gave tried?

My SHBG runs around 12, and I've felt better with E at 45 than 19. However, I've also felt great with E at 12. The difference...my total T/Free T levels. I think it's more of a ratio based on my results. Somewhere around 15 TT to 1 E. That's been my experience. The higher my T levels the higher my E levels. My high E and low E symptoms are very similar, so get the blood work done and keep anecdotal records. I've been at this for over a year, and it's still a work in progress.

 

[eli]

I'm one that sells the position that your E2 trough might need to mirror that SHBG value. This made a lot of difference for me. I have real positive progress when my E2 is in the single digits (trough). My body acne has cleared, sensitivity improved, orgasm is much better, lots of positives. Short of some erection issues that persist I'd be extremely happy.

I've too made the suggestion that maybe E2 should be managed from the peak, instead.

My Free Estrogen I've seen double to over the lab range @ 12hrs post injection on 14mg/D and that's with .25mg/D, too.

I over aromatase for no reason and I'm very sensitive to even a little too much E.

you have to keep in mind that E follows T, if you're looking at the trough alone thats just a low point...where is your PEAK?

We too know that SHBG binds E just like it does T, you could reasonably presume that if your Free T is over the lab range that your estrogen is following.

When guys say that they're doing great on X level of Estrogen you always have to account that the sides that they MAY be experiencing just aren't that problematic, to them. For me being hot and overly warm in bed at night doesn't sound all that bad, but it disrupts my sleep for hours and that's intolerable, for ME.

Doesn't work like that for me personally. When I did the cream, My E2 was btw 30-40 and I felt like a champ, SHBG was 13.