Drug and/or hormone-related hair loss

keigwin

Member
I'm 54 and have been on anastrozole and cabergoline for over a year. I've been treating high E2 and prolactin. I started with anastrozole and then, after seeing my E2 come down, added the cabergoline. I've normally got a good head of hair, but starting cab immediately caused noticeable hair loss. After a few weeks, I cut my cab dose in half and my hair started to regrow.

Fast forward to about 3 weeks ago and for some reason I started seeing hair loss again. I recently made minor changes to my dosing, but the amount of cab I'm taking is still far below what it originally was when my hair originally fell out. (anastrozole from 0.225mg -> 0.200mg E2D, cab from 0.0625 -> 0.0800mg E3D. previous hair loss at cab = 0.25mg E3D)

Would like any suggestions about what's going on here.
 
I understand. Since I stopped losing hair last year when I reduced the cab, it makes sense to suspect it. However, I'm now taking about 1/3 the amount that caused that hair loss, and my hair has been fine in the intervening year. I'm not sure why suddenly it would start up again.

Can I assume you would not recommend finasteride? I know some people have had bad experiences with it.
 
Finasteride is junk...horrible for libido, etc. I would try something topical like Lipogaine first (or plain azelaic acid cream...melazepam or The Ordinary) and an anti dht shampoo like regenepure dr or nizoral or something similar.

Edit: It's too bad the Empower hair loss topicals are so expensive. They're good stuff but about 3-4x the price they should be. I have tried most hair loss products myself but never topical finasteride (or latanaprost).
 
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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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