Does injection volume have any effect on pharmacokinetics?

The title pretty much says it all. Is there any difference in terms of absorption, half-life, metabolism, etc if 100mg of testosterone is administered in a 1mL quantity (100mg/mL) vs .5mL (200mg/mL)? My instincts tell me there has to be at least some slight variation. What about even smaller volumes, such as .1 mL (or less) in the case of daily injections? Do small volumes like this cause the drug to be metabolized more quickly irrespective of established ester half-lives?
 
I would say no, but with be more frequent injections you definitely get a more stable level of testosterone. I was injecting 100 mg of testosterone cypionate every three and a half days now that I'm doing daily I'm only using 16 mg a day. I was donating blood every 8 weeks now that I went to daily I haven't donated blood since last year in February. The steady level of T has definitely helped my HCT, it's not the same for everyone though.
 
The title pretty much says it all. Is there any difference in terms of absorption, half-life, metabolism, etc if 100mg of testosterone is administered in a 1mL quantity (100mg/mL) vs .5mL (200mg/mL)? My instincts tell me there has to be at least some slight variation. What about even smaller volumes, such as .1 mL (or less) in the case of daily injections? Do small volumes like this cause the drug to be metabolized more quickly irrespective of established ester half-lives?


Regarding metabolism/hepatic clearance shbg would play as strong role and hepatic blood flow.https://academic.oup.com/jcem/article/91/11/4669/2656842



The side chain ester/injection site and injection volume can influence the pharmacokinetics/pharmacodynamics of nandrolone esters which should also apply to testosterone esters.http://jpet.aspetjournals.org/content/jpet/281/1/93.full.pdf








 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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