Does having low Vitamin D reduce the effectiveness of TRT?

Stanfoo

Member
Been on many protocols, low and high dose, but noticed no perceivable changes mentally (i.e. libido, energy) - basically was just like injecting water.

I do have low Vit D (19 ng/ml, range is 25-100). Does anyone know if having abysmally low Vit D would reduce the effectiveness of TRT?
 
Does anyone know if having abysmally low Vit D would reduce the effectiveness of TRT?
It doesn’t matter if you have naturally high testosterone or on TRT, the vitamin D deficiency experience will be exactly the same.

Take it from someone who’s had either low vitamin D (<25) and vitamin D deficiency for almost a year with high testosterone, it’s as if I’m not even on TRT!

I went through 3 dosage increases and muscles were soft as dough, yet after one week supplementing 600 IU vitamin D, my muscle started getting hard again, libido and erections returned within days.

Vitamin D deficiency affects dopamine release mechanisms, and dopamine affects libido.

Without enough vitamin D, all the testosterone in the world won’t do s***! I found the same thing to be true with low iron.
 
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Been on many protocols, low and high dose, but noticed no perceivable changes mentally (i.e. libido, energy) - basically was just like injecting water.

I do have low Vit D (19 ng/ml, range is 25-100). Does anyone know if having abysmally low Vit D would reduce the effectiveness of TRT?
Do you have low so shbg?

 
I agree that low D will cause all sorts of problems , but other things will too such as low copper or low salt. I was just reading the part of the book The Salt Fix today that talks about low salt causing low libido and low energy.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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