Cortisol issues with HCG ?

at15

Active Member
We know the chain is HCG-->pregnenolone--->progesterone---->17-hydroxyprogesterone, which converts to cortisol. Is this why it is common to have issues with HCG? Seems people on the forum are moving away from HCG.
 
Increase in estrogen is a major issue with HCG. In men who were secondary it can cause estrogen issues.
 
We know the chain is HCG-->pregnenolone--->progesterone---->17-hydroxyprogesterone, which converts to cortisol. Is this why it is common to have issues with HCG? Seems people on the forum are moving away from HCG.
IN that same chain were we speculate or think we know HCG can start that downstream production, in most of us on the forum I think experience some sort of dysfunction in that area, maybe enzyme related. But obvious not working as one wouldn't need to use Preg or DHEA, et al.., if HCG would spur that conversion.
But moreso that HCG direct stims to the testes usually if it's going to give a guy problems, or perceived problems, it's going to be the aromatase in the testes.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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