Anyone have examples of TRT pharmacokinetic charts?

[anol1258]

Has anyone seen visual charts showing how testosterone levels change between TRT injections?
I'm curious whether the curves are smooth or if there are sharp peaks/drops, especially for the common esters like cypionate and enanthate.

Just looking to see what the typical pharmacokinetic profile looks like visually.

I found this post, but would like some more examples if available!:

Pharmacokinetic Profile of Subcutaneous Testosterone - Excel Male Health Forum

 

[Nelson Vergel]

Based on my search through the ExcelMale website, I found several testosterone pharmacokinetic charts and data points. Here's what I discovered:

Key Testosterone Pharmacokinetic Data from ExcelMale​

1. This case study measured testosterone absorption at multiple time points after scrotal application of 200mg testosterone cream. Key findings:​

• Peak levels: 1204.7 ng/dL within 2 hours (t-max = 2 hours)
• Sustained levels: 1320.6 ng/dL remained beyond 6 hours
• Half-life: 16 hours (extrapolated)
• Practical implication: 18 hours after application, testosterone levels drop to half the 2-hour peak ABSORPTION OF TESTOSTERONE CREAM VIA SCROTAL DELIVERY (2018) - Excel Male Men's Health Forum

2. The forum discussions reference a half-life table showing:​

• Testosterone Cypionate: 12 days (vs commonly cited 7 days)
• Testosterone Enanthate: 10.5 days
• Testosterone Propionate: 2 days
• Peak concentrations typically reached 24-48 hours after injection Testosterone half life table - Page 2 - Excel Male TRT Forum

3. A pharmacokinetic study showed:​

• Peak: 700-800 ng/dL reached within 30-40 minutes
• Return to baseline: By hours 2-3, levels drop back to starting point
• This creates a natural rise-and-fall pattern with each dose New Testosterone Natesto Data- Interview with Dr Ramasamy- Part 2 | Excel Male TRT Forum

4. Studies on oral testosterone undecanoate showed:​

• Peak time: 3-5 hours post-dose
• Peak levels: Mean Cmax of 1178 (±484) ng/dL
• Duration: Levels taper off by approximately 10 hours
• Pre-dose levels: Around 270 ng/dL Optimizing Oral Testosterone Undecanoate (Kyzatrex) TRT: All You Need to Know - Page 2 - Excel Male Men's Health Forum

5. The forum frequently references pharmacokinetic modeling tools:​

• SteroidPlotter: External tool for graphing testosterone levels over time
• Just1Cycle.com: Improved steroid plotter with customizable pharmacokinetic modeling
• These tools help visualize the "sawtooth pattern" of testosterone peaks and valleys Excel MaleExcel Male

6. Discussion of testosterone to estradiol conversion:​

• Simple model: Estradiol proportional to testosterone (0.3-0.6% conversion)
• Michaelis-Menten model: More sophisticated, accounting for saturation effects
• Charts showing how E2 rises and falls with testosterone injections Chart showing rise in E2 with T injection? - Excel Male Health Forum

Key References Mentioned​

The forum frequently cites the Lakshman study: "The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010" Excel MaleExcel Male