Advice on stopping or reducing AI?

rifter

New Member
I'm on a 120mg test C, 2000ui HGC and 1 mg anastrozole a week split into two doses.

Lab tests have historically been stable
Total & Free test is around 1200 - 1300
Free test is around 24 -26
E2 is between 22 - 35

My Doc wants me to stop anastrozole. After all the touted benefits of estradiol and research presented, I'm inclined to try follow his advice. I was initially put on anastrozole from day 1 of starting TRT 6 years ago. The HCG is obviously to maintain fertility.

My question is should I reduce the dose to 0.5mg anastrozole once a week or just drop it completely?
My next labs are due in just over a month.

Any advice here would be great - thanks!
 
I'm on a 120mg test C, 2000ui HGC and 1 mg anastrozole a week split into two doses.

Lab tests have historically been stable
Total & Free test is around 1200 - 1300
Free test is around 24 -26
E2 is between 22 - 35

My Doc wants me to stop anastrozole. After all the touted benefits of estradiol and research presented, I'm inclined to try follow his advice. I was initially put on anastrozole from day 1 of starting TRT 6 years ago. The HCG is obviously to maintain fertility.

My question is should I reduce the dose to 0.5mg anastrozole once a week or just drop it completely?
My next labs are due in just over a month.

Any advice here would be great - thanks!

Do you feel good? I'm a newbie, but from what I've read many would consider your E2 range to be in the "sweet spot." Seems to me that if it ain't broke, don't fix it.
 
Feeling good becomes relative to the time you've been following a specific protocol. I feel my "normal". I don't know If I would feel "better" or "worse" under a different protocol... it has been so long I honestly cannot tell.

Yes, 1000ui twice a week is high. I don't particularly want to change too change more than one variable at one time, so I'm reluctant to change the dosing schedule or amount at this point.
 

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HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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