Advice needed please re TRT, Doxasozin and ED

Norseman22

New Member
I've been on TRT for 6 months plus now.

250mg Sustanon per week and I had bad ED and with all the spots on my back, I realised I needed to get my Estrdiol down so added 0.5 - 0.75 mg of Aridamex per week in 2 or 3 doses. My ED recovered to 80% plus pre hypogonadism days for a few weeks and I didnt need pils to have sex. I was getting some discomfort urinating and suspected BPH and was getting up during the night to urinate. I added 2mg of Doxasozin to protect my prostate and my libido has gone. Sensitivity is way bad and I cannot climax apart from what I think is retrograde ejaculation (into bladder). Having researched Doxasozin I see 10% of users report libido issues and there is an alrming amount of men who now cannot climax due to taking this drug. Many never recover. My situation is now much worse than even when I took SSRI's a number of years ago. I have stopped the Doxasozin after 3 to 4 weeks use and I bought a months supply of Calis 5mg and will see if this improves my painful urination.

My tests came back and on the day before my next dose - My Results with ranges - Testosterone - 29.4 nmol/L (8.6 - 29), Sex Hormone Binding Globulin - 24 nmol/L (14.5 - 48.4) and Oestradoil - 82 pmol/L (28 - 156) and Free Testosterone 21.9 pg/ml (7.2-23)

Please could someone assist? Should I try to get my Oestradiol down even lower? Or could it be my creatine or something else too high/low. I have an appointment with an endo next week and if there is any specific test to ask for (other than recently done) what should be tested?

I hope the calis improves my ED.
 
I take daily doxasozin Cialis along with trt and hcg Libido is fine.....even slightly too much The real issue maybe estradiol. If that isn't in the right place it all goes to hell
 
I agree with the men above.

2 mg daily of Doxazosin is a very low dose of the drug and while we're all different I have a hard time believing it is suppressing libido...low E2 would be a culprit in my book.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
2
Guests online
205
Total visitors
207

Latest posts

Back
Top