hypogonadism

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* Chronic opioid use is a common but underappreciated cause of androgen deficiency in men. * Opioids suppress the gonadal axis mainly by inhibiting GnRH synthesis and secretion. The prevalence of opioid-induced androgen deficiency in men varies between 20% and 80% and is influenced by the type...

* T4DM RUNON sub-study extended the T4DM randomized, double-blind, placebo-controlled trial (n=1007) by 2 years, for a total of up to 4 years of treatment, without ongoing enrolment in the lifestyle program. Eligible and consenting participants (n=121) continued their original masked allocation...

* The available literature suggests BUP may impact male sex hormones to a lesser degree than full-agonist opioids. High-quality research is needed to explore the relationship between BUP and OIH in comparison to full opioid agonists and non-opioid controls...

* Male sexual symptoms are biologically heterogeneous and clinically nonspecific. Erectile dysfunction, reduced sexual desire, impaired spontaneous erections, and broader androgen-deficiency symptom clusters may arise from vascular, psychogenic, relational, neurological, metabolic, endocrine, or...

Testosterone is the talk of the town. Who should consider treating it and who shouldn't, and can lifestyle changes and supplements really make a difference? In this episode of MAN ALIVE, leading men's health specialist & GP Dr Jeff Foster gives a simple explanation of the benefits and...

Leydig Cell Implants! 11:55-24:00 Testosterone Deficiency Generation & Transcriptomic Validation of hiPSC-Derived Leydig Cells Generation of an Expandable Leydig Progenitor Population Physiologic-Conditions Drive Functional Leydig Maturation 3D Bioprinted...

* This study demonstrated that this novel oral TU safely and effectively increased T levels in hypogonadal men, with patients achieving mean serum T concentrations above 26 nmol/L by day 105. Of note, there were no clinically significant changes from baseline in liver function tests. The range...

* Dr. Patel emphasizes that real-world prescribing often differs from controlled trial conditions, particularly with injectable formulations that may result in higher testosterone peaks and greater hematologic effects. * Dr. Patel stresses the need for careful cardiovascular screening, patient...

Neson's Excel u heard! * Future research in the field of T assessment should prioritize multicenter validation of cFT against ED measurements of free T in diverse populations to confirm cFT as a robust and clinically accessible tool (see Outstanding questions). * Additionally, the growing...

If you’re searching late at night about erectile dysfunction, low testosterone, libido, or fertility, you’re not alone—and those questions can be an important clue about your overall men’s wellness. In this episode of Baptist HealthTalk, host Dr. Anthony Gonzalez sits down with Dr. Justin...

In this episode, Dr. Kevin Chu and Justin Dubin discuss the recent updates to testosterone therapy labels, debunk myths about prostate cancer risks, and explore the future of testosterone treatment and regulation. They emphasize the importance of evidence-based practice and evolving medical...

In this episode, Dr. Rena Malik sits down with Dr. Martin Miner, Dr. Larry Lipshultz, and Dr. Tobias S. Kohler to unpack the myths and realities of testosterone therapy. The conversation covers who truly benefits from testosterone treatment, how guidelines are evolving, distinctions between...

JAMA Medical News Director Jennifer Abbasi and Associate Managing Editor Kate Schweitzer discuss “Testosterone Therapy: Does New Evidence Warrant Broader Prescribing?”

Patiently waiting! Hubert W. Vesper, Ph.D How can laboratories and researchers ensure tests used in patient care and clinical research produces accurate and comparable results...

* Severe energy deficit, sleep disruption, and uncontrollable psychogenic stress suppress hypothalamic gonadotropin-releasing hormone and luteinizing hormone pulsatility, reduce testicular androgen production, and frequently increase sex hormone–binding globulin (SHBG), thereby...

But while Khera supports screening, he said he worries about inappropriate use of TRT. “I wouldn’t treat someone with TRT if they weren’t symptomatic” or had normal testosterone levels, says Khera, who helped publish seminal research on TRT and in 2025 led a U.S. Food and Drug Administration...

Standardized testosterone assays are available and improve accurate diagnosis of hypogonadism and ensure men who need treatment receive it. The use of a testosterone assay that has been certified by the CDC HoST program ensures that the assays have been standardized and “harmonized”; results...

* The particular threshold of 700 ng/dL chosen for this study demonstrated the greatest, most significant difference in CAG repeat length between the two groups. * In the cohort with complete follow-up data (n=75), patients whose testosterone levels superseded 700 ng/dL following therapy...

* Testosterone plays an important role in the maintenance of male skeleton. Most studies of testosterone therapy have demonstrated some degree of improvement in BMD * Based on elegant mechanistic studies (discussed below), the current thinking is that both testosterone and estradiol are...

In part one of this men’s health series, Dr. Eve Glazier and Jesse Mills, MD, health sciences clinical professor of urology and director of the Men’s Health Clinic at UCLA Health, examine how symptoms such as erectile dysfunction can offer important insights into overall health. They discuss why...

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, is joined by renowned male reproductive specialists Larry I. Lipshultz, MD, and Dolores J. Lamb, PhD, to discuss the science, clinical value, and future of the male infertility laboratory. Drawing on decades of collaboration in...

https://www.bcm.edu/healthcare/clinical-trials/h-56187 Description An Open-Label Multiple-Dose, 52-Week Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents (ages: 12 to <18 years) With Conditions Associated with Deficiency...

* Bhasin noted that, like fellow academics and endocrinologists, he has historically been cautious around testosterone therapy. “In the last 5 years or so, we’ve learned a lot more, and I’ve changed my position,” he said. “On one side, it’s very rigid, and on the other, it’s touted as the cure...

How do you protect your prostate, recognize the early signs of erectile dysfunction, and separate medical facts from internet myths? In this episode, Tom (he/him) sits down with Dr. Arthur Burnett (he/him), renowned Johns Hopkins urologist, researcher, and one of the pioneers behind the science...

https://www.linkedin.com/pulse/new-official-german-mens-health-portal-section-fcpfe Prof Dr med Dr hc Michael Zitzmann, MD. PhD, FRSM https://www.maennergesundheitsportal.de/themen/testosteronmangel-bei-maennern/

https://endo2026.endocrine.org/searchGlobal.asp Background Testosterone therapy is widely used for male hypogonadism but suppresses gonadotropins, reducing intratesticular testosterone and impairing spermatogenesis. These effects contribute to testicular atrophy, infertility, and increased...

* The findings support the Endocrine Society’s recommendation that direct IAs should not be used in clinical practice. https://endo2026.endocrine.org/fsPopup.asp?PresentationID=1845305&mode=presInfo Free testosterone (FT) is widely used in clinical diagnosis, management, and research of...

In this episode, Dr. Brandon and Dr. Morgentaler talk about the FDA's groundbreaking testosterone label changes, the evolving evidence on testosterone therapy and prostate cancer, and how quality of life should factor into treatment decisions for men with advanced disease. Time stamps...