Androgen Sensitivity Is an Important Contributor to Treatment Response

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8th Annual Meeting of the Androgen Society 2026 presentations from the top experts in the field!




Professor T. Hugh Jones

Testosterone Cut Off Values from Guidelines

CONCLUSIONS

Hitting the nail on the head here!

* The panel unpacks why “normal ranges” don’t fit every individual, highlighting genetic differences in androgen receptor sensitivity (CAG repeats) and the need to tailor treatment to symptoms and biology rather than numbers alone.


4:20-6:07

* so we have been developing a blood test which is a testosterone CAG repeat ratio. So the higher your testosterone and your lower your CAG repeat you will have a higher sensitivity of androgenization. So that's how you can work it out. We've also shown that when testosterone is given, if someone has a high CAG repeat, which is low sensitivity, they don't respond unless you get the testosterone in the HIGHER NORMAL RANGE.

Thread 'Testosterone replacement therapy (TRT), and what the latest evidence really tells us about safety, cancer risk, and healthy ageing in men'

Dec 26, 2025

Hitting the nail on the head here!

* The panel unpacks why “normal ranges” don’t fit every individual, highlighting genetic differences in androgen receptor sensitivity (CAG repeats) and the need to tailor treatment to symptoms and biology rather than numbers alone.


4:20-6:07

* so we have been developing a blood test which is a testosterone CAG repeat ratio. So the higher your testosterone and your lower your CAG repeat you will have a higher sensitivity of androgenization. So that's how you can work it out. We've also shown that when testosterone is given...

• madman
• hypogonadism mens health t therapy
• Replies: 4
• Forum: Testosterone and Men's Health Articles

 

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ANDROGEN RECEPTOR ACTIVATION WITHIN THE TARGET CELL

CAG repeat Polymorphism of the AR gene

CAG Repeat Polymorphism in Type 2 Diabetes Patients

 

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Modulation of androgen effects

Effect of GAG Repeat Number on Biological and Medical Parameters

 

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Androgen Receptor Sensitivity and Testosterone and LH levels in Type 2 Diabetes (n = 203)

ANDROGEN RECEPTOR INSENSITIVITY CORRELATES WITH GREATER INCREMENT IN HbA1c AFTER 14 YEARS

ANDROGEN RECEPTOR SENSITIVITY IS ASSOCIATED WITH INCREASED MORTALITY IN MEN WITH TYPE 2 DIABETES

Effect of Androgen Receptor Sensitivity to Testosterone Replacement] in Metabolic Syndrome and Type 2 Diabetes: TIMES2 Study

 

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SYMPTOM RESPONSE AND CAG POLYMORPHISM : TESTOSTERONE THERAPY IN MEN WITH HYPOGONADISM

AMS (Aging Male Symptom) Score for Quality of Life and Symptoms of Testosterone Deficiency

Symptom Response at 6 months

 

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Descriptive statistics as baseline

ARCAG distribution in non-responders and responders

Non-Responders after 12 months Testosterone Therapy

 

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NEW CONCEPT TO ASSESS ANDROGEN STATUS AND ADEQUATE TESTOSTERONE THERAPY

STUDY ON A POPULATION OF MEN WITH ALL CAUSE HYPOGONADISM EXAMINING EFFECT OF CAG POLYMORPHISM AND TESTOSTERONE CAG RATIOS ON DIAGNOSIS

BIO/CAG Ration and HBA1c, Body Composition in T2DM

BIOAVAILABLE/CAG Ratio on HDL-Cholesterol in TYPE 2 DIABETES (n = 195)

 

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Comparison of Elements for Diagnosis

Predictive Performance Response to. Testosterone Therapy using T Gels

 

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CONCLUSIONS