Advice on TRT lab levels - high estradiol and hematocrit

Lance69 · Feb 21, 2026

I'd appreciate any advice on my labs.

I am on the Crisler protocol. 25 units HCG on Tues Wed, .8cc Test cyp 200mg/ml on Thurs.

Low libido wood issues persist.

My Labs - pre Thurs testo shot:

RBC - 6.58
Hemoglobin - 19.5
Hematocrit - 60.0
Testosterone - 700
Estradiol - 54.1
PSA - 1.9

Thanks to the resident experts for any input.

Nelson Vergel · Feb 22, 2026

I would lower my T to 100 mg per week, keep the hCG at 250 IU twice per week, and get therapeutic phlebotomy. Even with one blood donation, your hematocrit will still be high at 56-57. I would wait a month to do another blood donation.

Stay hydrated and take a baby aspirin.

Your estradiol is not high, specially if it was tested using the old test assay (not sensitive).

Lance69 · Feb 22, 2026

Thanks Nelson. I've done a lot of digging on this and want to try the following and redo labs in a few weeks.

Mon - .4cc test cyp
Tues - HCG 250 iu
Wed -
Thurs - .4 test cyp
Fri - HCG 250 iu
Sat -

Then I will likely scale back on the T shots little by little based on the labs. Thoughts?

Nelson Vergel · Feb 23, 2026

Why the letrozole? Many guys regret having taken it.

Was your E2 measured by sensitive analysis ( LC/MS) ?

Lance69 · Feb 23, 2026

Nelson Vergel said:
Why the letrozole? Many guys regret having taken it.

Was your E2 measured by sensitive analysis ( LC/MS) ?

My dr recommends Letro. Maybe now that I will start to reduce my T and go to twice a week I won't need the Letro. He was trying to bring down my E2 with it, but you think reducing my T and going to 2x a week might correct the E2 and libido issues, so I will try that for a while without the Letro and see how I do.

Many thanks Nelson.

Lance69 · Mar 2, 2026

Thanks Nelson. I'm going to follow your guidance and make some adjustments to my schedule using chatgpt. I'll stay on this for a while to see how my estradiol and hematocrit do.

Any input welcome.