Peak vs trough testosterone level

[sh1973]

Have there ever been any large studies that give an accurate range of what a typical range/percentage there is between the low and high points of a testosterone injection. For instance, I have always did best with once weekly low dose and currently do 52mg per week. My trough has been 640-660ng day seven morning of my next shot. I would like to know where I’m peaking and most likely just need to get labs but was curious if there is a range verified through studies? At one point I checked levels when doing 100mg per week and 3 days after injection I was close to 1500ng. At 100mg my trough was over 1000ng.

 

[WhiteMale]

Ive often thought and believed that peak over trough is where we should be looking. Its a flaw in how TRT is sold to guys as in we'll keep you at the LOWEST point high physiological if not supraphysiological.
Most guys with E problems, which is most all, usually overlook the fact that their number of 29 on a LCMSMS test, which by the numbers looks good and they can't understand why they still have E symptoms and problems.

 

[sh1973]

Ive often thought and believed that peak over trough is where we should be looking. Its a flaw in how TRT is sold to guys as in we'll keep you at the LOWEST point high physiological if not supraphysiological.
Most guys with E problems, which is most all, usually overlook the fact that their number of 29 on a LCMSMS test, which by the numbers looks good and they can't understand why they still have E symptoms and problems.

I agree and honestly think labs midway would be a better window to see what’s happening.

 

[Cataceous]

You can estimate the peak-trough ratio based on the half-life of the testosterone ester. The estimate I use for weekly injections of testosterone cypionate is 2.5, which stems from a five-day half-life. This would put your peak at over 1,500 ng/dL. However, half-lives vary among individuals, so yours could be longer—meaning slower absorption—yielding less dramatic peaks. This is supported by your report of a drop from 1,500 ng/dL to ~1,000 ng/dL in about four days. These numbers put your half-life closer to seven days, and would reduce your predicted peak to more like 1,300 ng/dL. Your relatively high SHBG means these numbers for total testosterone are not as extreme as people might think. For example, with TT at 1,300 ng/dL and SHBG at 60 nMol/L your Vermeulen calculated free testosterone is about 23 ng/dL, which is close to the top of the healthy normal range for young men. A trough TT of 650 ng/dL puts cFTV at around 10 ng/dL, which is high enough to avoid being hypogonadal.