My prescribed dose is two pumps in morning and one at night equal to 150mg not sure if I should just do 100
I would start with 2 clicks in the morning after a shower and get a
testosterone test at week 3, right before your next dose.
Get the test here:
Testosterone, Free, Bioavailable and Total, Immunoassay
This T test results get back faster than the LC/MS test. Depending on the results, you can adjust the dose.
The label on the container indicates that the testosterone cream contains:
Testosterone Micronized 200 mg/g.
The usual prescribed dose written on the label is:
0.5 gram (2 clicks) applied topically per day
That equals 100 mg of testosterone daily, since 0.5 grams × 200 mg/g = 100 mg
Some providers may start with 0.25 grams (1 click = 50 mg) daily, depending on the patient's baseline testosterone levels, symptoms, age, and absorption considerations.
Typical compounding topical testosterone doses range from:
25 mg to 100 mg daily (0.125 g to 0.5 g of this 200 mg/g formulation)
Application sites usually include the shoulders, inner thighs, or scrotum (depending on instructions and absorption goals)
Because absorption varies among individuals, dosing is often adjusted based on follow-up blood tests (usually total and free testosterone levels measured 2–6 hours post-application on steady state).
STEADY STATE TIME:
For testosterone creams applied daily, the usual steady state is typically reached within:
14 to 21 days (2–3 weeks) of consistent daily use¹².
However, some studies suggest steady serum testosterone concentrations may begin to stabilize as early as 7–10 days, especially with daily application and appropriate skin site absorption. Full pharmacokinetic equilibrium—where the rate of absorption equals the rate of elimination—typically occurs by 14 days, with minimal further fluctuations beyond that point under consistent dosing and application conditions³.
Important Notes:
Daily application is essential due to the short half-life of testosterone in topical formulations (roughly 8–14 hours, depending on the base and application site)⁴.
Blood levels should be checked after reaching steady state, usually at 2–4 weeks, and ideally 2–6 hours after morning application to assess peak absorption⁵.
Variability in absorption due to skin site, hydration, temperature, and cream base (e.g., lipoderm vs. Versabase) can influence both time to steady state and overall effectiveness.
References
Wang, C., Swerdloff, R. S., Iranmanesh, A., Dobs, A., Snyder, P. J., Cunningham, G., Matsumoto, A. M., & Berman, N. (2000). Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. Journal of Clinical Endocrinology & Metabolism, 85(8), 2839–2853.
https://doi.org/10.1210/jcem.85.8.6747
Guay, A. T., Perez, J. B., Fitaihi, W. A., & Vereb, M. (2003). Testosterone treatment in hypogonadal men: prostate-specific antigen level and risk of prostate cancer. Endocrine Practice, 9(1), 17–19.
https://doi.org/10.4158/EP.9.1.17
Swerdloff, R. S., Wang, C., Cunningham, G., Dobs, A., Iranmanesh, A., Matsumoto, A. M., ... & Berman, N. (2000). Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. Journal of Clinical Endocrinology & Metabolism, 85(12), 4500–4510.
https://doi.org/10.1210/jcem.85.12.7071
Dobs, A. S., Meikle, A. W., Arver, S., Sanders, S. W., Caramelli, K. E., & Mazer, N. A. (1999). Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men. Journal of Clinical Endocrinology & Metabolism, 84(10), 3469–3478.
https://doi.org/10.1210/jcem.84.10.6066
Morgentaler, A. (2022). Testosterone deficiency: A clinician’s guide (3rd ed.). Springer.
