Could my low E2 (~10.0) have caused my herniated disc?

JCUSN

Member
At only 34, I’ve somehow herniated a disc in my cervical spine. This hasn’t happened before, until I stopped TRT and I’ve been doing an unsuccessful restart. Total T at 225, E2 at 10.0.

Is this low E2 low enough to cause bad inflammation or loss of cartilage to the point one will slip a disc? It has only been a little over a month that I’ve had these low values.
 
Doubt it, before I started trt my estrogen levels were unreadable. I've never had any back issues except for a broken pelvis. The broken pelvis was caused when I fell from a high height when I was a bricklayer.
 
At only 34, I’ve somehow herniated a disc in my cervical spine. This hasn’t happened before, until I stopped TRT and I’ve been doing an unsuccessful restart. Total T at 225, E2 at 10.0.

Is this low E2 low enough to cause bad inflammation or loss of cartilage to the point one will slip a disc? It has only been a little over a month that I’ve had these low values.
Im 100% sure, no.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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