My updated hormone protocol:
So far things have been good. I esp. like the reduction in hunger and water retention that came from decreasing testosterone
- Sex hormones (lowered my dosage): Testosterone cypionate (40mg subcutaneously 2x/week), HCG (125iu subQ 2x/week), FSH (50iu subQ 2x/week), anastrozole (0.25mg/week) (For more info on how I replace male sex hormones, click here.)
- Adrenals (same dosage): 20mg hydrocortisone-equivalent per day (split into five daily doses), 0.05mg fludrocortisone, 25mg DHEA, 6.25mg pregnenolone
- Thyroid (increased my dosage): 62.5mcg T4 and 4x5mcg T3 taken 6h apart. (Click here for more info.)
- GH/IGF1: 0.5 IU GH in the morning
Yes, I believe this to be true as well. It should be noted though, that the reverse is also true for some (esp. if hormones are abused at high doses): namely, although rarely, some people do not recover their baseline hormones at allI always notice people post and say "when you come off, you return to your orignal baseline". As you have pointed out, this is not nessesarily true. I believe while "on" a cocktail of hormones, if the user takes steps to vastly improve their health and athletic performance, the now healthy body is able to remain healthy when the hormones are ceased. This could mean a higher setpoint for certain hormones.
Update: After using HC for around 2 years, I was able to get off the HC, effectively resetting my HPA-setpoint to a higher baseline. I have now been off all HC for 4 months and I feel perfectly fine. Also, HC is the most dangerous, difficult, and most cumbersome hormone to replace so I am glad I was able to reset my HPA-axis.
Yes, I believe this to be true as well. It should be noted though, that the reverse is also true for some (esp. if hormones are abused at high doses): namely, although rarely, some people do not recover their baseline hormones at all
What is your body weight and height??
I get the impression you are not that tall from your protocol, Im wondering what the adjustment would be for me.
I read through your blog, and really appreciate the effort you went to. I didn't have cortisol issues before I got a severe infection, before then I was doing fine on TRT and thyroid, but I have had very little energy until I was put on prednisone.
I am 26y male on TRT,hcg, thyroid and was on prednisone. I was doing alright, but was on high dose prednisone due to an infection and crashed adrenals which I can see is not good for you and suppresses everything. I'm trying to shift to hydrocortisone but suffer severe fatigue tapering down. I want to switch to hydrocortisone full replacement and closer to your protocol before you went off HC.
I am 185cm,72kg. Taking 100mg sustanon a week (2 injections), hcg 150iu x 2 a week, prednisone 2.5mg and hydrocortisone 10mg a day, NDT 2 grains, 75mg T4.
Similar to you I found lower testosterone and hcg was better, I may need lower but I cant tell with the crashed adrenals. I may also need lower thyroid but again can't tell.
I run for 1 hour 10 mins every day, which maybe means I need more HC.
I'm thinking of switching to 20mg hydrocortisone spaced out 7.5mg 5mg 2.5mg 2.5mg 2.5mg. And adding pregnenolone 10mg a day, DHEA 25mga day, and melatonin 0.5 as I don't sleep that well, now I'm on wellbutrin because of low mood/energy.
Let me know if you have any thoughts on my protocol
Do you know of a way to get prescribed growth hormone in Europe?Hello,
I can promise that over the long term you are running into problems with this protocol (likely). Also, your thyroid is way too high (at least judged on the dosage). And you running this much exacerbates your issues. I feel uncomfortable making specific suggestions here on an open forum. Furthermore, I´d need to have a lot more background information about you. You may contact me via the email provided in my articles.
Yes, glad my hypothalamus was never damaged in the first place (which it certainly might be for some people!).Thanks for the update—that's really impressive. Congrats!!
It does seem like if you dial in, got a stable life, and everything then slowly wean off one thing your body can work out the homeostasis.
Do you plan to try and get off the thyroid now, as this has been a success?
Also what is your resting heart rate/sleeping heart rate and blood pressure—This would be really helpful for me to know, as I have got a similar body to you but a bit taller/skinnier.
Which cortisol tests (total, free, AM, PM, etc.) were you using?After weaing off GH and cortisol, these two axes are now at higher levels than they were before. On this weeks blood test ACTH was at the 85th percentile (very pulsatile so take it with a grain of salt), cortisol at the 75rth percentile, and IGF1 at around the 75th percentile as well.
Hell.Good luck! I know thyroid takes a long time to clear, so will have to wait a couple of. Months to be completely sure.
I'm looking at your hormetheus website again, do you have your heart rate, blood pressure, sleeping heart rate?
Also when was the latest you took cortisol when you were taking it? and did you stress dose when feeling a bit run down.
Generally, cortisol is incredibly hard to test for. I have seen an elevated cortisol many times in total cortisol, but often CBG is high. Generally, a good indicator of adrenal health is DHEA-S. Other than that, in my experience, urinary and salivary cortisol are not worth much. The best may simply be a trial and error of a small dose of HC (e.g. 5mg). If you strongly feel it, you may assume that cortisol is low. If you feel nothing, then cortisol is likely not your problem.Which cortisol tests (total, free, AM, PM, etc.) were you using?