How does Thyroid hormone effect Estrogen and Aromatase?

[kashman112]

I have searched for the answer endlessly and only got conflicting reports . Does Thyroid hormone ( T4,t3) reduce Estrogen or raise it ? What is their effects on the aromatase enzyme ?

Thank you . All seems very confusing and I think the TRT/testosterone community could benefit from the correct answer immensely .

 

[Systemlord]

Thyroid hormone controls thermogenesis and energy balance, especially the liver, which breaks down the estrogen and eliminates it from your body. If your liver isn’t functioning correctly, too much estrogen can accumulate.

As far as high estrogen is concerned, this may not apply to men on exogenous T, because you’re well above the natural daily release of 5-7 mg on TRT. If you’re particularly sensitive to estrogen, this can present problems.

 

[kashman112]

Does it upregulate or downregulate the aromatase enzyme ? I have read two studies that give conflicting answers . One study says it downregulates it , the other study says that it upregulates it and caused Gynecomastia in some men when they were hyper .

 

[Systemlord]

Does it upregulate or downregulate the aromatase enzyme ?

Thyroid hormone inhibits aromatase activity in porcine thecal cells cultured alone and in coculture with granulosa cells - PubMed

We cultured porcine thecal and granulosa cells alone or in coculture to define whether thyroid hormone affects aromatase activity in porcine ovarian cells. Dispersed cells were cultured with 10(-9) M triiodothyronine (T3) for 24 hours. Testosterone (final concentration 10(-7) M) was added as...

pubmed.ncbi.nlm.nih.gov

T3 inhibited cAMP analogue 8-Br-cAMP and FSH-induced aromatase activity to a similar extent, thus suggesting that the inhibitory effect of T3 is downstream of cAMP formation.

Pretreatment of Th and Gc with T3 markedly decreased immunostaining for aromatase in both types of cells, suggesting a direct effect of T3 on this enzyme.

The Role of Thyroid Hormone in Testicular Development and Function

Thyroid hormone is a critical regulator of growth, development and metabolism in virtually all tissues, and altered thyroid status affects many organs and systems. Although for many years testis has been regarded as a thyroid hormone unresponsive organ, ...

www.ncbi.nlm.nih.gov

Thyroid hormone was shown to decrease aromatase activity in Sertoli cells by direct inhibition of the aromatase gene transcription

 

[Coconutz]

Thyroid hormone inhibits aromatase activity in porcine thecal cells cultured alone and in coculture with granulosa cells - PubMed

We cultured porcine thecal and granulosa cells alone or in coculture to define whether thyroid hormone affects aromatase activity in porcine ovarian cells. Dispersed cells were cultured with 10(-9) M triiodothyronine (T3) for 24 hours. Testosterone (final concentration 10(-7) M) was added as...

pubmed.ncbi.nlm.nih.gov

The Role of Thyroid Hormone in Testicular Development and Function

Thyroid hormone is a critical regulator of growth, development and metabolism in virtually all tissues, and altered thyroid status affects many organs and systems. Although for many years testis has been regarded as a thyroid hormone unresponsive organ, ...

www.ncbi.nlm.nih.gov

Jeez. just one more thing men with aromatase deficiency need to be aware of.