cypionate dose protocols for woman

[madman]

This is going to be a common theme here!

Endocrine treatment of transgender individuals

Endocrine treatment of transgender individuals: current guidelines and strategies Abstract Introduction: This review provides a summary of the medical and surgical care available to transgender individuals, as well as to offer proposals on how the medical field can progress to provide...

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2. Hormone regimens for transgender men

The primary goal of masculinizing HT is to stimulate physical changes consistent with the patient’s gender identity. Testosterone is the sole hormone administered. The aim is to achieve levels within the physiological range for cisgender men (300-1000ng/dL). There are several routes available to administer exogenous testosterone (Table 2). These include subcutaneous or intramuscular injections, transdermal gel or patches, and subcutaneous implants. With regards to achieving desired physiologic levels, no data support one route of administration over another, but higher testosterone levels are more easily achieved with parenteral treatment [5].

Injectable testosterone preparations include testosterone enanthate (TE), testosterone cypionate (TC), and testosterone undecanoate (TU). TE and TC can both be given as subcutaneous injections every week to ten days, or intramuscularly every two to three weeks. Typical doses for the weekly administration are 50 to 100mg [9]. These doses can be doubled and given with greater dosing intervals to reduce frequency of injections, although this is associated with greater fluctuation in levels [10]. With a longer carbon side chain, TU has a significantly longer half-life than TE and TC [11] [12], and can therefore be administered every 12 weeks [13]. Due to the fact that transgender men tend to be smaller in size than cisgender men, it may be advisable to begin with lower dosing and titrate upwards to avoid supraphysiologic levels.

Testosterone gels are typically given at doses of 50-100 mg/d, while transdermal patches are given at 2.5-7.5 mg/d [13]. Patients are advised to keep the application site clothed for 4 hours after administering gels to avoid skin-to-skin contact with others. Patients are also advised to avoid showering for 4 hours to ensure absorption [14]. Due to high levels of pruritus reported with use of patches, gels tend to be more commonly prescribed than patches'

Implantable testosterone pellets are also available, but titration will be more straightforward with shorter acting agents, leaving pellets reserved for maintenance [13]. Pellets contain 75mg of active ingredient and up to 6 can be inserted at once. Two pellets are typically inserted for every 25mg of parenteral testosterone required weekly and most patients require repeat implantation every 3 to 4 months.




2.1 Treatment effects

Although many transgender men desire maximum virilization, others may wish more modest results. Unfortunately for the latter, the impact of even low dose hormone therapy cannot be reliably predicted for any given individual and patients should be prepared for a range of results.

Within 3 to 6 months of initiating masculinizing therapy, transgender men can expect to experience amenorrhea, increased libido, coarsening of skin and acne, fat redistribution, increased muscle mass, and facial hair growth [15] [16] [17]. Over longer periods of time, patients can experience voice deepening and clitoromegaly [18] [19]. Male pattern hair loss can also occur due to the androgenic interaction with pilosebaceous hair follicles [20]. Some transgender men may welcome this change as it can be considered masculinizing, but some do not. Male pattern hair loss has been managed with 5alpha- reductase inhibitors, but patients should be counselled regarding reports of sexual function concerns, along with the lack of evidence for objective benefit in transgender men [21]. Height will not be affected by HT administered after puberty

For the majority of adult transgender men who began HT after puberty, a degree of nonreversible physical feminization will have occurred. Many transgender men will therefore be shorter, have a degree of female fat distribution [22], and have broader hips than cisgender men [23]. Patients can expect some degree of breast atrophy with long-term androgen therapy with studies showing histological changes [24] in breast tissue of transgender men with reduced glandular tissue and increased fibrous connective tissue comparable to changes seen in post-menopausal women [25] [26]

Comparing Subcutaneous Testosterone to Intramuscular Testosterone in Gender Affirming Care of Transgender Male Adolescents

Comparing Subcutaneous Testosterone to Intramuscular Testosterone in Gender Affirming Care of Transgender Male Adolescents - Full Text View - ClinicalTrials.gov Study Description Brief Summary: The trial studies the efficacy of subcutaneous (SQ) testosterone compared to intramuscular...

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Hormone therapy of FTM transgender patients: searching for a lifelong balance

Abstract Background Reassignment of a female-to-male (FtM) person requires gender-affirming, the androgenic hormonal treatment that is planned to induce appropriate structural changes. This therapy must be prolonged long term, even after the sex reassignment surgery (SRS). The purpose of this...

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Serum hormone concentrations in transgender people

SERUM HORMONE CONCENTRATIONS IN TRANSGENDER INDIVIDUALS RECEIVING GENDER AFFIRMING HORMONE THERAPY: A LONGITUDINAL RETROSPECTIVE COHORT STUDY Objective: To examine the association of various gender affirmation hormone therapy (GAHT) regimens with blood hormone concentrations in transgender...

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Transmen on TRT: Hormones Ranges

Reproductive Endocrinology Reference Intervals for Transgender Men on Stable Hormone Therapy Dina N. Greene, Robert L. Schmidt, Gabrielle Winston-McPherson, Jessica Rongitsch, Katherine L. Imborek, Jane A. Dickerson, Julia C. Drees, Robert M. Humble, Nicole Nisly, Nancy J. Dole, Susan K. Dane...

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Serum Hormone Concentrations in Transgender Individuals Receiving GAHT

abstract Objective: To examine the association of various gender-affirming hormone therapy regimens with blood sex hormone concentrations in transgender individuals. Methods: This retrospective study included transgender people receiving gender-affirming hormone therapy between January 2000...

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Physical and Psychological Effects of TRT in Tras Men Using IM-TE in Japanese TGM

ABSTRACT Introduction: The evidence on gender-affirming hormonal treatment (HT) for transgender persons is still insufficient. Aim: To characterize the physical and psychological effects of HT using testosterone enanthate in transgender men, and to validate the safety of this treatment...

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Sub-q T Is Effective and Safe as GAHT in Transmasculine and Gender-Diverse Adolescents and Young Adults

Abstract Purpose: To describe our Center’s 8-year experience with subcutaneous testosterone (SC-T) as gender-affirming hormone therapy (GAHT) in transmasculine and gender-diverse (TM/GD) youth. Methods: An Institutional Review Board (IRB)-approved retrospective study for 119 TM/GD subjects who...

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Hormonal Gender Reassignment Treatment for Gender Dysphoria

Summary Background: No data are available at present on the prevalence of gender dysphoria (trans-identity) in Germany. On the basis of estimates from the Netherlands, it can be calculated that approximately 15 000 to 25 000 persons in Germany are affected. Persons suffering from gender...

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Health Care for Transgender and Gender Diverse Individuals

ABSTRACT: An estimated 150,000 youth and 1.4 million adults living in the United States identify as transgender. This Committee Opinion offers guidance on providing inclusive and affirming care as well as clinical information on hormone therapy and preventive care; it also cites existing...

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Clitorophallus modifications in transgender care

Abstract Background: The clitorophallus, or glans, is a critical structure in sexual development and plays an important role in how gender is conceptualized across the lifespan. This can be seen in both the evaluation and treatment of intersex individuals and the use of gender-affirming...

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Gender Affirming Hormones in Youth

Abstract An increasing number of transgender and gender-expansive adolescents are seeking gender care at clinics and hospital programs and requesting gender-affirming hormonal treatment. Many are approved for this form of care to enhance their gender health. The interventions can either include...

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Gender-affirming hormone therapy

Abstract In line with increasing numbers of transgender (trans) and gender non-binary people requesting hormone treatment, the body of available research is expanding. More clinical research groups are presenting data, and the number of participants in these studies is rising. Many previous...

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Treating Acne in Transgender Persons Receiving Testosterone

Abstract Transgender persons who undergo masculinizing hormone therapy experience a wide array of dermatologic effects as they initiate and maintain testosterone therapy. Acne is one of the most common adverse effects for many transmasculine patients receiving testosterone. Acne can worsen...

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Transgender and Gender Diverse Patients

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Transgender Clinical Chemistry Reference Intervals

Reference Intervals for Clinical Chemistry Analytes for Transgender Men and Women on Stable Hormone Therapy (2022) Robert M. Humble, Dina N. Greene, Robert L. Schmidt, Gabrielle Winston McPherson, Jessica Rongitsch, Katherine L. Imborek, Nicole Nisly, Nancy J. Dole, Susan K. Dane, Janice...

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Endocrine Testing in Transgender Individuals

https://arup.utah.edu/education/straseski-inclusivity-2022.php Choosing the right laboratory test for any clinical situation can be difficult. One particularly complex situation is choosing appropriate testing for transgender and nonbinary patients. Gender and sex are words that many use...

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The efficacy, safety, and outcomes of testosterone use among transgender men patients

The efficacy, safety, and outcomes of testosterone use among transgendermen patients: A review of the literature (2022) Rimel N. Mwamba | Adaora Ekwonu | Paulo V. B. Guimaraes | Omer A. Raheem Abstract Introduction: Gender dysphoria is the discrepancy between biological sex and gender...

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[BigTex]

Reduced Breast Size

Once again, I have know quite a few female BBers and have never seen one of them loose any breast size through anything but diet. My wife included. Once they start back eating again the fat come right back and the breast look just the same.

Enlarged Clitoris (Clitoromegaly)

This definitely happened with my wife. However, it does seem to enhance sex and orgasms greatly. Now once stopping the larger doses it diminishes in size greatly. This same thing happens to women who have never used testosterone. This same thing can happen when aldosterone and DHEA-S get out of control from perhaps a polycystic ovary syndrome. Getting it from using testosterone is sure not the end of the world.

Cessation of Menstruation

Again @madman, my wife has a period all of her adult life and in fact bled much more than most women. She stopped her period in her mid 50 as most women do. She also got pregnant using testosterone when doctors said it could not happen. I realize what science tells us but there is so little know about what happens when women use testosterone. Lots of these changes depend greatly on genetics and ethnicity. Look how many Sematic, Indian and Pakistani women have facial hair and none have ever taken steroids. How many Latin American woman have dark hair on their arms similar to a man.

I love science but there is just not much known about anabolic steroids taken by women. Its only been the past few years that we realized women may need TRT just like a man. The dosing is constantly changing. The Women’s Health Initiative (WHI) in 2002, which showed that HRT had more detrimental than beneficial effects, so the idea of using testosterone replacement in women was dropped. Its been since about 2012 that this idea was reversed.

 

[testiculus]

The Women’s Health Initiative (WHI) in 2002, which showed that HRT had more detrimental than beneficial effects, so the idea of using testosterone replacement in women was dropped. Its been since about 2012 that this idea was reversed.

A more accurate statement would be that NIH wanted to curtail the use HRT in women and created a study to produce the desired outcome. The result was the WHI which was a dumpster fire of scientific malpractice. Entire books have been written about the WHI misconduct: Estrogen Matters by Avrum Bluming and Carol Tavris. Unfortunately the idea pushed out by the WHI in their famous press conference, that HRT is bad for women (even though their own data didn't support their statements), persists to today.

It is my view that there is no intervention for women that has a greater impact on health and longevity than HRT. The Nurse's Health Study showed lower overall mortality for women who received HRT vs those that didn't, with a very large reduction in cardiovascular disease. Nurses’ Health Study: Estrogen associated with lower cardiovascular disease risk. I can't find the source data on overall mortality at the moment, but the effect size is huge. If I remember correctly it's about the same difference as one would get if you could completely cure all cancer.

 

[BigTex]

Guys here is an example of a woman who my wife knows who was an IFBB PRo. Media is really good at showing pictures like this and the public and obviously those in science thinks this is what happens to women who use testosterone. Well this is what female BBers look like close to a contest when they get that hard, emaciated look from diet which ended up killing the sport.

here is what the same woman looks like when she isn't on that hard diet:

Obviously this is still a big woman but the face has filled out, she still has hair and from what I understand she still likes men.

Here is a pro in the IFBB physique division which replace BBing. Yea, she also does anabolic steroids.

Here is where women came from back in the 80's, still on steroids, a much softer, more feminine look she the rules should have been kept.

Our media and science has attached a horrible stigma to woman's use of testosterone. Especially now that they equate women using testosterone to transitioning too a man and then use female bodybuilders to show what will happen. A female will have to have some very good genes and train exceptionally hard with weight and suffer like she has an eating disorder to ever get in this kind of shape. Many women using TRT doses of testosterone will never have any side effects, especially if they stick to the short esters which are much more controllable. What we are doing is psychologically scaring women out of ever trying this despite how many here have seen the great results their wife's have had.

@testiculus this is my view as well - "It is my view that there is no intervention for women that has a greater impact on health and longevity than HRT." Yet our medical community and researchers want to deny women this treatment just like they did with men for years.

 

[MarcoFL]

Normal testosterone production in women is on the order of 500 mcg per day, equivalent to 5 mg T cypionate per week, though 2.5 mg twice-weekly would make for more stable levels. This corresponds well to cream protocols with ~5 mg applied per day and 10% absorption. There is research showing that improving libido in post-menopausal women can require supraphysiological testosterone levels, thus double these doses is not uncommon.

2.5MG 2X per week puts my wife in a great spot top end to just over. Any larger dose it is just to much! This along with her estradiol patches she is great.

 

[Cataceous]

2.5MG 2X per week puts my wife in a great spot top end to just over. Any larger dose it is just to much! This along with her estradiol patches she is great.

Any progesterone?

It seems plausible that on average the best results would occur when testosterone is paired with physiological levels of estradiol. These aren't necessarily provided by the aromatization of — physiological — testosterone alone. If a doctor is involved was there any discussion of risks/rewards in the use of estradiol?

 

[MarcoFL]

She is 59 nice shape about same build when we married 41 years ago. She sees a HRT doctor and on full program including 150mg oral progesterone, estradiol patch-not sure on dose and the 2.5mg 2X per week of T cypionate. She had been on creams but all over the board! if she does not take her progesterone she literally CANNOT sleep. If she takes more T than the 5mg per week she has orgasms in the night and less desire for sex then. Slow and steady wins the race. Highly recommend any woman to look at this program. The results have been very positive.

 

[mike7]

Dr. Irwin Goldstein has stated that women have 5X more testosterone than estrogen, throughout their entire lifetime.

I’m guessing that his credentials far exceed just about anyone on the planet.

 

[GreenMachineX]

My wife is on 10mg test cyp once per week right now and I do her shots for her. She has to go out of town for 2 weeks, so I'm wondering would it be better to double one dose before she goes, or have her just miss a shot until she gets back? Her doing the shot herself isn't an option lol.

Thanks.

 

[FunkOdyssey]

My wife is on 10mg test cyp once per week right now and I do her shots for her. She has to go out of town for 2 weeks, so I'm wondering would it be better to double one dose before she goes, or have her just miss a shot until she gets back? Her doing the shot herself isn't an option lol.

Thanks.

Sending your wife travelling for two weeks hopped up on a double dose of testosterone seems like a good way to encourage infidelity. If it were me I think I'd just let her miss a dose.

 

[GreenMachineX]

Sending your wife travelling for two weeks hopped up on a double dose of testosterone seems like a good way to encourage infidelity. If it were me I think I'd just let her miss a dose.

Lol didn't think of that. Would it work that quickly?

 

[FunkOdyssey]

Lol didn't think of that. Would it work that quickly?

It's possible.

 

[Willyt]

If she takes more T than the 5mg per week she has orgasms in the night and less desire for sex then.

Damn! Men would flock to TRT if they experienced the same

 

[MarcoFL]

My wife is on 10mg test cyp once per week right now and I do her shots for her. She has to go out of town for 2 weeks, so I'm wondering would it be better to double one dose before she goes, or have her just miss a shot until she gets back? Her doing the shot herself isn't an option lol.

Thanks.

I would NOT do the double dose!!! thats a lot my wife is at 5mg per week split in two.

 

[Belekas]

I have Test Prop 10ml vial ready for my girl just need to run some blood tests to see where shes at and then its go time. Thinking to start as well at 5mg/week split E3.5D and see how she feels. Might be too low, might be not, who knows, but I think starting low and titrating is a better strategy then going higher right out the gate. Been months with NHS trying to get a referral to the Menopause clinic and we still don't have it. Will update once the process starts.

 

[FunkOdyssey]

I have Test Prop 10ml vial ready for my girl just need to run some blood tests to see where shes at and then its go time. Thinking to start as well at 5mg/week split E3.5D and see how she feels. Might be too low, might be not, who knows, but I think starting low and titrating is a better strategy then going higher right out the gate. Been months with NHS trying to get a referral to the Menopause clinic and we still don't have it. Will update once the process starts.

I haven't heard of women using test prop, but I assume they would typically need a daily or EOD protocol like most men on that ester to keep things more stable.

 

[Belekas]

I haven't heard of women using test prop, but I assume they would typically need a daily or EOD protocol like most men on that ester to keep things more stable.

I discussed this dosing with Readalot when he was still around these ends. I'm not buying the stable level thing as well mate as its not natural to me. On a bad day it will be lower then on a good day and will fluctuate and keeping stable levels on tilt doesn't sound too good to me either. So I'm skeptical here.

 

[MarcoFL]

Do it correct...See a doctor and go on cypionate....no need to make this complicated and possible set up for possible failure....

 

[Belekas]

Do it correct...See a doctor and go on cypionate....no need to make this complicated and possible set up for possible failure....

No worries and we have no cyp where I am at. Nobody said that its getting complicated. I've been in this game a long time and glad to do it all myself. Everything is planned and talked through with really smart people. Thanks for caring though.