How Low Testosterone Secretly Destroys Your Health ft Dr. Mohit Khera

[madman]

IS MORE TESTOSTERONE BETTER.....NAH!

ALL THOSE BROZZZ LEFT SCRATCH N THA NOGGINS LMFAO!

DIME A DOZEN CLUB AT IT'S FINEST!

STINKIN UP ALL THOSE SO CALLED HRT/MEN'S HEALTH FORUMS!

F**KING SHAMEFUL!

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Dr. Mohit Khera, renowned urologist, researcher, and expert in male and female sexual health, joins Dr. Rena Malik to discuss the global decline in testosterone, why symptoms matter more than blood test reference numbers, and the crucial role of free testosterone. They dive into types of testosterone replacement therapies—including injectables, gels, orals, and pellets—their risks, benefits, and considerations around fertility. The conversation also covers how semen analysis serves as a window into overall health, the influence of lifestyle changes (like weight loss, sleep, and stress management) on hormone levels, and the relationship between testosterone, cardiovascular health, depression, and prostate cancer. Dr. Khera and Dr. Malik explore regenerative therapies for erectile dysfunction, including hyperbaric oxygen, shockwave therapy, stem cells, PRP, and Botox, and discuss lesser-known issues such as post-finasteride syndrome and the status of sexual health in women.




Chapters:

00:00:00 – Introduction
00:02:10 – The Testosterone Decline
00:06:07 – Free vs. Total Testosterone
00:11:32 – TRT Options
00:14:19 – Oral Testosterone & Fertility
00:17:26 – Protecting Fertility on TRT
00:20:38 – Recovery After TRT
00:29:10 – The Power of Estrogen
00:38:48 – Boosting Testosterone Naturally
00:42:31 – Stress & Operator Syndrome
00:50:12 – ED & Shockwave Therapy
00:55:13 – Regenerative Therapies
01:36:24 – Closing Thoughts

 

[madman]

Is there a number where you think that most people will reach full saturation or have full sensitivity of all their androgen receptors?

Going out to all the BROZZZ brainwashed by that more T is better mentality bullSHIT!

Listen closely 8:22-11:20

00:06:07 – Free vs. Total Testosterone




Dr. Khera hitting the nail on the head!

Everyone so caught up on needing those so called high-end/high trough FT!

24:22-25:07

* activation of the receptor goes long beyond what you see in the blood

Thread 'Age-stratified reference ranges for directly measured (ED LC-MS/MS) serum free testosterone in healthy men'

May 11, 2024

Just to be clear up any confusion this is Fiers camps data for mFT reference ranges not the harmonized reference range being worked on by the CDC.


*Serum samples were analyzed from healthy men participating in the SIBLOS/SIBEX and EMAS studies, both population-based cohort studies

* mFT levels were measured in 867 men using ED LC-MS/MS as previously reported (1). Subsequently, 95% reference ranges were determined using the non-parametric method


Reference: 1. Fiers T, Wu F, Moghetti P, Vanderschueren D, Lapauw B, Kaufman JM. Reassessing Free-Testosterone...

• madman
• free testosterone; ed/refernce range; tth
• Replies: 4
• Forum: Testosterone and Men's Health Articles

Thread 'CDC STANDARDIZED TOTAL T and ESTRADIOL ASSAYS and soon to be FREE TESTOSTERONE!'

Jan 5, 2019

How the CDC Clinical Standardization Programs Are Improving Hormone Tests - AACC.org

WHAT PROGRESS HAS CDC MADE WITH STANDARDIZING TOTAL TESTOSTERONE AND ESTRADIOL TESTS?



Since HoSt began in 2010, CDC has had more than 350 participants in 15 countries. Participants have shown measurable improvements for both total testosterone (TT) and estradiol (E2). Specifically, the among-laboratory bias has decreased from 16.5% in 2007 to 2.8% in 2017 for TT and from 54.8% in 2012 to 13.9% in 2017 for E2. Not only has bias improved, but data...

• madman
• Replies: 72
• Forum: Blood Test Discussion

• 

Thread 'Effect of Androgen Receptor Polymorphism on Hypogonadism Severity'

Oct 19, 2024

*Average number of CAG repeats found was 23 ± 3.1, which is within the normal range as described by current literature

* Half of the patients (n=8) had [EF] subscores <14, indicating erectile dysfunction. However, Wilcoxon testing reveals that this difference is not significantly less than the cutoff (p=0.4375), a result likely due to the small sample size. These findings are consistent with the literature, which suggests that a correlation between CAG repeat length and erectile function only exists in eugonadal men.

* These data suggest that CAG repeat...

• madman
• hypogonadsim; polymorphism ar/cag repeat length
• Replies: 3
• Forum: Testosterone and Men's Health Articles

 

[madman]

00:29:10 – The Power of Estrogen (28:40-30:41)

Thread 'Estrogen-It's what makes a real man'

Sep 24, 2022

https://www.nbcnews.com/nightly-news/video/study-low-estrogen-can-cause-problems-for-men-47991875700

Study: Low estrogen can cause problems for men (2013)​

Dr. Joel Finkelstein, an endocrinologist at Harvard Medical School and the lead author of a new study, talks about the effects of declining estrogen in men.

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​

​

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men (2013)​

Joel S. Finkelstein, M.D., Hang Lee, Ph.D., Sherri-Ann M. Burnett-Bowie, M.D., M.P.H., J...

• madman
• estrogen; testosterone; hypogonadism
• Replies: 40
• Forum: Testosterone and Men's Health Articles

• 

Thread 'Metabolic benefits afforded by estradiol and testosterone in both sexes'

Sep 3, 2024

Enjoyed this one!

As we very well know T s metabolites estradiol and DHT are needed in order to reap full beneficial effects of testosterone.

Ts metabolites estradiol and DHT are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects on (cardiovascular health, brain health, libido, erectile function, bone health, tendon health, immune system, lipids, and body composition).








*Anecdotally, male patients on TRT often enquire about their E2 levels due to fear of “too much female hormone.” Men s’ health clinics even prescribe aromatase...

• madman
• testosterone; estradiol; dht; metabolic health
• Replies: 4
• Forum: Testosterone and Men's Health Articles

• 

 

[madman]

00:14:19 – Oral Testosterone & Fertility

Thread 'Updates in testosterone therapy - Oral T combination Therapy'

Apr 28, 2025

* Sun explains how oral testosterone formulations—thanks to their short-acting pharmacokinetics—can preserve some endogenous testosterone production, unlike traditional injections that often completely suppress it.


* He details how he customizes treatment plans by blending oral testosterone with agents like Clomiphene to boost hormonal levels without fully shutting down the body's own system, offering a more physiologically balanced solution for men who may want children in the future.


* Later, they delve into combination therapy strategies, including using oral...

• madman
• hypogonadism; oral t/kyzatrex; trt; fertility/hpta
• Replies: 2
• Forum: Testosterone and Men's Health Articles

 

[madman]

Thread 'Testosterone Therapy and Erythrocytosis - the most common dose-limiting effect of testosterone therapy'

Apr 21, 2024

Testosterone Therapy and Erythrocytosis • The Blood Project

Introduction Androgens play a crucial role in the development and maintenance of: Male reproductive and sexual functions Body composition Erythropoiesis

www.thebloodproject.com

Introduction

• Androgens play a crucial role in the development and maintenance of:
  
  • Male reproductive and sexual functions
  • Body composition
  • Erythropoiesis
  • Muscle and bone health
  • Cognitive function
• Testosterone falls progressively with age and a significant percentage of men over the age of 60 years have serum testosterone levels that are below the lower limits of young...

• madman
• hypogonadism; testosterone; hematocrit; cvd
• Replies: 12
• Forum: Testosterone Side Effect Management

• 

 

[madman]

Thread 'Dynamic landscape of therapeutic options for T deficiency in reproductive-aged males and their impact on suppression of the HPG-axis'

Yesterday at 2:19 PM

Most up to date paper!

As usual Nelson house is where its at!

Exogenous T formulations impact on suppression of the HPG axis.

Here is a quick breakdown from most--->least suppressive!

As we have stated numerous times on the forum ultra short-acting Natesto is where its at!




Table 1 | Formulations of testosterone replacement therapy and their effects on male reproductive parameters

Published effects on FSH and LH


LONG-ACTING FORMULATIONS

Nebido/Aveed: Complete or near complete suppression

T-pellets: Strong suppression (90% reduction)





INTERMEDIATE-ACTING...

• madman
• hypogonadism; fertility/sperm; tth;
• Replies: 12
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T