Zinc and high estradiol

I have not found a scientific reference that links zinc blood levels or supplementation with high/low estradiol.

Several studies show zinc to be involved in testosterone and sperm production.

Systems Biology in Reproductive Medicine, 1981, Vol. 7, No. 1 : Pages 69-73
Effect of Zinc Administration on Plasma Testosterone, Dihydrotestosterone, and Sperm Count

The effects of zinc therapy on plasma testosterone (T), dihydrotestosterone (DHT), and sperm count were studied in 37 patients with idiopathic infertility of more than five years duration. In the first group (T < 4.8 ng/ml; 22 patients), T and DHT rose significantly after oral administration of zinc, as did the sperm count. Nine wives became pregnant, six within 3 months and three within 2 months of a second trial. In the second group (T > 4.8 ng/ml; 15 patients), T and sperm count were unaffected by zinc, while DHT increased significantly. There was no conception observed. The rationale of this treatment and the significance of the results are discussed.
 
I can say anecdotally that I had high estrogen (172pmol/L) and I took zinc (50mg/day) and LEF Super Miraforte (4 capsules/day) for two months and follow up blood work showed that my estrogen had dropped down to 133pmol/L. No other variables were involved.
 
I guess for healthy guys like you guys pill burden (that is what we call it in my world) is not an issue, although dosing more than twice a day has been linked to high drop out and lack of adherence in many studies. But since most of us have three meals a day, most guys can do OK taking pills with each meal. I would watch liver enzymes since we put a lot of trust on supplement companies that may be adding extra stuff.
Example:
OxyElite Pro Supplements Recalled
 
I take 50mg of Zinc daily. It helps with a number of things. I take it to keep from getting colds, helps with diabetes and said to help with BPH and ED but not sure about that last one. has not helped me... LOL
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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