(XXX) Products for Pain: Ineffective, Expensive, and With Potential Harms

[Deleted member 43589]

Well folks, This pretty well sums up what I believe after using quite a few different product to relieve pain.

Highlights​

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  Cannabidiol (XXX) products have varying amounts of XXX, from none to much more than advertised.
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  XXX products may contain other chemicals than XXX, some of which may be harmful.
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  Sixteen RCTs for pain used pharmaceutical XXX in oral, buccal/sublingual, and topical forms.
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  Fifteen of the 16 RCTs were negative: no greater pain-relieving effect for XXX than for placebo.
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  Meta-analyses link XXX to increased rates of serious adverse events and hepatotoxicity.

Abstract​

Cannabidiol (XXX) attracts considerable attention for promoting good health and treating various conditions, predominantly pain, often in breach of advertising rules. Examination of available XXX products in North America and Europe demonstrates that XXX content can vary from none to much more than advertised and that potentially harmful other chemicals are often included. Serious harm is associated with chemicals found in XXX products and reported in children, adults, and the elderly. A 2021 International Association for the Study of Pain task force examined the evidence for cannabinoids and pain but found no trials of XXX. Sixteen XXX randomized trials using pharmaceutical-supplied XXX or making preparations from such a source and with pain as an outcome have been published subsequently. The trials were conducted in 12 different pain states, using 3 oral, topical, and buccal/sublingual administration, with XXX doses between 6 and 1,600 mg, and durations of treatment between a single dose and 12 weeks. Fifteen of the 16 showed no benefit of XXX over placebo. Small clinical trials using verified XXX suggest the drug to be largely benign; while large-scale evidence of safety is lacking, there is growing evidence linking XXX to increased rates of serious adverse events and hepatotoxicity. In January 2023, the Food and Drug Administration (FDA) announced that a new regulatory pathway for XXX was needed. Consumers and health care providers should rely on evidence-based sources of information on XXX, not just advertisements. Current evidence is that XXX for pain is expensive, ineffective, and possibly harmful.

Perspective​

There is no good reason for thinking that XXX relieves pain, but there are good reasons for doubting the contents of XXX products in terms of XXX content and purity.

https://www.jpain.org/article/S1526-5900(23)00582-5/fulltext

 

[Alspersk]

It's crucial to have honest discussions about XXX products, especially when it comes to pain relief. The inconsistency in XXX content and the presence of potentially harmful chemicals are definitely concerning.