Why do some men need supraphysiological doses of testosterone to achieve normal levels

[FunkOdyssey]

So I take it your sleep eventually normalized at the higher doses?

Yes it did.

 

[Gianluca]

I didn't ask if you have ruled out fast absorption. To do this properly you need several samples of serum testosterone during the day to estimate area-under-the-curve. But it might suffice to see what your testosterone level is two to fours hours post-injection. If it is extremely high then you might suspect it's more about absorption than metabolism.

I have not, thanks for bringing this up.

Since injecting everyday, I generally get the blood draw about 2hrs post injection, but sometime I believe I went prior injection, and levels come back about the same.

However, I have gone in the past in the late afternoon, and TT seems to come back higher probably about150/200ng/dl more on ED protocol. My last TT result in April was 765ng/dl confirming the extra 200ng/dl or so. This intramuscularly.

I remember in the past that every time after increasing the dose, or a time where I switched from subQ to IM, I would feel the change from day 1. Let's say I would inject in the am, by the late afternoon I could already feel the more testosterone, or perhaps the metabolites. This on a 2 or 3 injection protocol IM.

All of this makes me think I should try again subQ, since to my understanding there is a more gradual release of Test into the blood this way.

 

[MarcoFL]

100mg split daily keeps me over 1000TT and at the top of FT for me at 62. My wife 61 in nice shape only for walking is on 4-5mg per week split in two doses is quite high and has a HUGE libido from it. We really just keep an eye on hematocrit and how we feel. We both drink probably 4 plus liters a day of spring water so never a hematocrit issue with high T levels. We both have A1c of 5.1 and very happy with that.