When HCG is Added to TRT

There are plenty of studies demonstrating that common practice in TRT is to take once weekly injections. However, we know that many men feel better and that it’s significantly more physiological to microdose with EOD test injections. Not all do it by any means, but it is becoming the more optimal manner of administration.

The same can be said of Clomid. Does Clomid have to be take ED? No. Just as testosterone does not have to be taken ED or EOD, but it is more physiological and optimal to do so. Dr. Crisler always suggested taking lower ED doses as opposed to larger EOD doses to reduce side effects.

Dr. Ramasamy and Dr. Lipshultz also suggest this practice as a preferred treatment method.

“For those patients desiring to establish a pregnancy within 6 months, testosterone therapy should be discontinued, and treatment begun with 3000 IU hCG ± clomiphene citrate (25 mg daily) and a semen analysis performed every 2 months.”



You went on a tangent about test injections and that’s not even the subject matter I mentioned. Once again, Clomid doesn’t need to be taken daily. Your own study that you sent even says the protocol I mentioned, NOT DAILY. Here it is...
Treatment was initiated with administration of 25 mg of clomiphene citrate every other day with a target total serum testosterone level of 550 ± 50 ng dl−1 . For those patients not meeting the target level, doses were titrated up to 50 mg.
I’m not telling you a daily dose is wrong but eod is certainly not irregular.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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