What is the best dose of HCG? Dr Saya presents two case studies.

VigorousSteve on YouTube (and others) claim that HCG loses its full potency 2-3 weeks after reconstituting the powder with BAC water. He said people often tell him that the HCG stopped working, but he tells them to start a new vial and see if it feels different. And everyone comes back and says "hey it's working now!"

I now agree with him based on my experience with Pregnyl in the USA. Pregnyl comes in 10,000iu powder, and I am taking 300iu EOD, so it would last me about 9 weeks. But after weeks 3-4, things definitely felt different in testicular size and labido. I haven't started a new vial yet mainly because my compounding pharmacy charged me $300 for it, so I'm just upping my doses 50-100iu more until I finish it in a few weeks.

I will probably buy HCG from another source that is under 5,000iu going forward, like a 2,500iu vial. Has anyone else noticed diminishing effectiveness of an HCG vial after 3 weeks?
 
HCG is good for 90 days in the fridge based on the studies. I used mine for 30 days per vial, and my sperm count was perfect on it when I used it. So, I call this bulshit....
 
Heres an interesting real world test that some people did on meso-rx



"This is a work in progress of testing reconstituted HCG for degradation after 30, 45 and 60 days stored between 2-8 degrees celsius as advised. Posting this with slight delay as I needed to check that it matched the contents of pharmaceutical HCG to exclude this as a variable.
...
~18% degradation after 31 days
~50% degradation after 45 days"


That thread also links to this study:

Which showed about the same degradation rates.
 
HCG is good for 90 days in the fridge based on the studies. I used mine for 30 days per vial, and my sperm count was perfect on it when I used it. So, I call this bulshit....
Can you link to studies? Pregnyl labels says stable for 60 days when refrigerated. I saw another drug medical site say throw away HCG after 30 days.

I found this thread that claims 90 days too, but no sources. [EDIT: same link @Speed provided above, he posted while I was still writing]
 
Heres an interesting real world test that some people did on meso-rx



"This is a work in progress of testing reconstituted HCG for degradation after 30, 45 and 60 days stored between 2-8 degrees celsius as advised. Posting this with slight delay as I needed to check that it matched the contents of pharmaceutical HCG to exclude this as a variable.
...
~18% degradation after 31 days
~50% degradation after 45 days"


That thread also links to this study:

Which showed about the same degradation rates.
Looks like HCG potency goes downhill real fast after 30 days (need to double the dose by day 45), according to their experiment.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
6
Guests online
392
Total visitors
398

Latest posts

Back
Top