Is there any new information (e.g., studies) regarding trying to replicate the natural daily fluctuation of testosterone of an adult male at peak health?
I'm asking because a few months back I switched to daily injections of testosterone phenylpropionate (based on the bits and pieces of relevant info. in this forum).
No T formulation other than the T-patch (Androderm®) applied before bed would be the closest to achieving this!
It was discontinued 2018 in Canada and 2023 in the US by its manufacturer, AbbVie (formerly Allergan).
As I have stated numerous times on the forum over the years when it comes to most closely mimicking the 24 hr natty circadian rhythm of a healthy young male the transdermal T-patch
(Androderm®) applied before bed holds the title!
Even then when we are speaking in terms of natty healthy young men those peak T levels achieved are a daily short-lived peak to boot!
Natural endogenous testosterone secretion is pulsatile and diurnal.
During the natural 24-hour circadian rhythm of a healthy young male T levels will start rising gradually overnight reaching a peak (highest point) in the early AM followed by lower levels in the late afternoon and reaching trough (lowest point) in the evening.
Fluctuations from peak--->trough would be around 20-25% (higher in some cases).
One daily peak/trough.
They have a healthy hpta to boot!
Drastic difference here compared to the majority of the men on TTh who are running high FT levels 24/7 and top it off that many are hitting a high/absurdly high trough FT whether injecting daily, EOD, twice-weekly (every 3.5 days), M/W/F or god forbid once weekly!
Strong suppression of the hpta and throw in HAMMERING the shit out of your DOPAMINE to boot!
I was using Prop Subq ED @ .13ml (I've been as high as .2ml and as low as .1ml, but .13ml was enough for me where I felt best).... I like prop precisely because of the trough (high in early day and low at night which is closest to natural test peak/low levels)... I've always struggled with sleep while on trt but for me prop is the lesser of the other 2 evils from Enan and Cyp, as I feel I get a little bit better sleep on prop.. also, I think my E is easier to control as I don't really need Adex like I do on enan/cyp and I don't carry alot of water weight. PS- I jab...
This is key here!
(i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening. Based upon these criteria, only the Androderm® transdermal patch (Figure 3D), when applied in the evening (∼22:00 h) as recommended, closely mimics the TT circadian rhythm of normal young adult males.
* The TT concentration produced by the Androderm® transdermal patch applied to the skin of the back, stomach, upper arms, or thighs nightly before retiring to sleep more closely reproduces the normative TT circadian pattern of young adult males than any of the other marketed PA-TRTs. Following application, TT concentration progressively rises during sleep and peaks around the time of morning awakening; it progressively declines during late morning and afternoon, reaching its nadir (Cmin) in the evening before the next scheduled patch application (Figure 3D).
* The TT level produced by the Androderm® transdermal patch system when applied as recommended in the evening before bedtime most closely simulates the normal physiologic pattern. In this regard, the high and low limits of normal TT in the graph of this PA-TRT found in the package insert are unique (Figure 3D); they are depicted in a time-varying cyclic, rather than a time invariable constant, manner that takes into consideration the normal high-amplitude TT circadian variation of diurnally active healthy young men(https://www.accessdata.fda.gov/ drugsatfda_docs/label/2011/020489s025lbl.pdf). This is in distinct contrast to the manner in which the high and low limits of normal are depicted in the package insert of all the other PA-TRTs (Figure 2A-2F and Figure 3A-3C), that is, as constant values consistent with the presumed homeostatic perspective of human biology and endocrinology. Such a homeostatic perspective drives the recommended procedures of dose assessment and titration, although with inconsistencies between the different PA-TRTs in the recommended time of day when to conduct them (Table 2).
as far as pharmacokinetics, if I remember correctly, scrotal cream applied once per day only is the closet to mimic endogenous T production. Too bad the DHT issue classify it far away from physiologic to me.
No that title would go to the T-patch (Androderm) applied before bed!
This is key:
(i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening. Based...
Keep It Up: The Power of Precision Medicine to Conquer Low T and Revitalize Your Life! Hardcover October 8, 2013 by Florence Comite - I read this book a couple of years ago and thought it was really good. I read the kindle version. She talks about men feeling their best, when having their testosterone levels, at the levels they were, when they were young. She believes young men should have their levels tested, so when they get older they know what to shoot for.
Most older men had higher levels when they were young. Of course, most young men having to start out on TRT had low...
you blood work was at peak(ish). prop has high peak/low low. you need to blood work in the morning before injection. there is a reasons most clinics have patients in the 120-180mg range on TRT. again - all individual - so if you do great on a low dose, not dismissing it by any means go for it.
you can also argue that at those low doses TRT does not make a lot of sense, as most people can achieve those levels naturally by modifying diet/lifestyle. chasing any lab is pointless. on the flip side, on such doses you will miss out on many of the TRT benefits, raised DHT (especially with...
