I think I am getting it all wrong with dose frequency - High SHBG and poor sleep

Sandz

New Member
So I've been trying to dial it in for 8 months, starting dose from my doc was 120mg 1x IM. I soon switched to 2x a week sub Q because the peaks were literally keeping me up all nigh, felt like I was on speed, I was too much at the especially at the beginning. I'm a little dude, 165lb, not that it matters, but 4 weeks in I got labs, didn't know Id need a sensitive tests, and I was over 1500. That was in Feb, so I have leaned a lot, had many labs and studied how I feel and my sleep/recover/workouts etc.

8 months in and the below numbers are total dose per week split. I know for sure I was switching too often, sometimes only giving it 4 weeks, not 6 or better yet 8, I know.

120mg 2 x a week
100mg 2 x a week
80mg 2 x a week, 826 through Monday AM furthest out from Friday shot. SHBG was 47. Albumin was 4.4, E was like low 20s sensitive. (free T calc 1.84%)

Thought I would get more androgenic benefit and more even stable numbers at 3x a week so
back to 90mg 3x a week though.

Then to 84mg 3x a week - 1134 through Monday AM furthest out from Friday shot. SHBG was 70. Albumin was 4.6, E was mid 30s so probably even lower sensitive but no symptoms, E is under control. (free T calc 1.54%)

Now at 78mg 3x a week, thinking I will get close to the 80mg numbers and sleep well, but I think I am doing it wrong 3x and still not sleeping. I think I am learning that there is more aromatase activity at 3x per week and this whole time I thought it would stabilize. Is it accurate that slightly longer troughs means less aromatase activity overall? Does more frequency mean slightly higher transient SHBG-suppressing effects, but temp peaks help suppress SHBG? I guess the serum level stays more consistent but the SHBG is higher, am I on to something? I don't feel that different at 826 vs 1134, I felt fine...I think :)

I am going to ride this out for 8 weeks, 3 weeks in, but If I test again and SHBG is still up, keeping my free T lower than it could be, who cares what the total is.....If I can get a better net effect on a lower dose, I think I will try that. If I was at 800+ before, going back to 78mg (close to 80, easy to measure) If I can get around the same and good free T ratios, the overall sleep and androgenetic benefit would be better, ya? Bottom line, and last question is, is it possible I'm just a 2x a week kinda guy?
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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