TRT Peaks and troughs or steady levels. Which is correct?

[busydad]

I'm a bit confused. I'm considering starting TRT. I'm trying to decide on injecting or oral. My doctor prescribes either one but says he prefers sub-q injection 2x per week. Where I'm confused is I see arguments for both therapies. Some folks say the peaks and troughs of orals is best cause it mimics our body's natural rhythm. The I see others stating it's good to have steady state of higher test at all times.

The reason I'm considering the oral is because E2 is always very high. I've been having labs done going back 15 years and my Estradiol has never been in range. It's usually between 50 - 80. I really don't want to go on a aromatase inhibitor so it seems like the oral may be my best option.

Would daily injections work the same as the oral?

Thanks

 

[Vince]

I'm a bit confused. I'm considering starting TRT. I'm trying to decide on injecting or oral. My doctor prescribes either one but says he prefers sub-q injection 2x per week. Where I'm confused is I see arguments for both therapies. Some folks say the peaks and troughs of orals is best cause it mimics our body's natural rhythm. The I see others stating it's good to have steady state of higher test at all times.

The reason I'm considering the oral is because E2 is always very high. I've been having labs done going back 15 years and my Estradiol has never been in range. It's usually between 50 - 80. I really don't want to go on a aromatase inhibitor so it seems like the oral may be my best option.

Would daily injections work the same as the oral?

Thanks

We have a few threads on oral testosterone. You may find this one interesting.

Thread 'My Experience On Jatenzo (Oral TRT) Log'

Jun 16, 2021

I wanted to start a thread detailing my personal experience with Jatenzo (oral TRT) which is remarkable in how quickly it has shown results when compared with injections. The first week on Jatenzo was very pleasant unlike my experience after dosing changes on injections, all with minimal swings and I felt things stabilize on day 7 which is where things felt consistent.

The first few days on Jatenzo my glucose levels were the lowest, then over the next two and a half weeks I would see glucose levels fluctuate wildly and at the end of week three a return to those same lower fasting and...

• Systemlord
• jatenzo oral testosterone
• Replies: 378
• Forum: Testosterone Basics & Questions

• 

 

[Cataceous]

It's a good question, without a definitive answer. There's too much individual variation to say whether you'd find the differences to be subtle or profound. Neither modality produces a natural-looking diurnal rhythm in serum testosterone. However, men can have good results with either. Twice-weekly injections of testosterone cypionate actually do yield pronounced peaks and troughs, with a 50% reduction from peak to trough being typical. It's only when you get to daily or EOD injections that levels can become fairly static.

Personally I have come to favor having intra-day variation, though I have not used oral testosterone to attain it. Also, my point of comparison is static levels from EOD testosterone enanthate.

With your concerns about estradiol it does seem as though oral testosterone is the better choice. However, I'd encourage you to start with something even faster acting if possible, such as testosterone nasal gel, before resorting to a form of TRT that results in significant suppression of the HPTA.