Thinking of going back to twice weekly injections-- your thoughts? And trying to judge the right TRT regimen when you have a venous leak

[DDD]

I have been on TRT for about 4-5 years now. I am thinking of going back to twice weekly injections. Have been doing once weekly for about 1.5 years now. I inject .75cc of T cyp on Mondays, take .25 mg of anastrozole on Tuesday or Wednesday, then .1mg anastrozole on Friday and Sunday. When I do labs, my T is usually around 1100-1300 on Wednesdays with E2 of around 21-22. If I don't take the anastrozole by Tuesday, the day after injection my E2 has measured 53. By Friday, before I take the .1 mg of anastrozole my E2 is around 30. On Monday before my next injection, my T has measured 495-700, with my E2 between 11-17. All these are the sensitive E2 labs. I'm not sure I like the 700-800 point T swing from the beginning of the weekly cycle to the end.

What do most guys do? Do they benefit more from twice weekly or more frequent injections of lower dosages? Or do most guys do fine on once weekly?

The thing that complicates this for me is that I have been diagnosed with a venous leak which makes erections difficult. Since I have always associated libido with having erections, it makes it difficult for me to know which TRT regimen is working for me? Having the venous leak causes me tension and stress and I wonder if that tension and stress is nullifying some of the effects of the TRT.

Am I making sense with my explanation? How do you judge your TRT regimen when you have a venous leak?

 

[fifty]

Twice weekly is generally better than once weekly for many reasons (less dip, less e2, etc).

 

[DDD]

On once weekly, I usually feel a libido spike the day of injection or the next day. I take 150 mg (.75cc) on the once weekly shot. I then take .25mg of anastrozole the day after injection, but sometimes I sense the anastrozole decreases the libido spike. Would the libido be more consistent on a twice weekly or more frequent schedule?

The other question is--- how do you switch from a once weekly to twice weekly? For example, I take my once a week injection on Mondays. If I switch to twice weekly, do I start the smaller dosage on Thursday (3 days after my Monday weekly injection), or do I wait a whole week and start the twice weekly on a Monday, which would be 7 days later?

On twice weekly I'd probably do a Mon/Thur schedule with T cyp of 70-75 mg each injection and .1 mg anastrozole the day after injection.

Lastly, what are some reasons guys would choose to do an E3D or EOD regiment?

I know it's a lot of questions, just looking for answers. Thanks.

 

[S1W]

FYI you now have 3 consecutive posts all asking more or less the same questions.

If you are currently injecting 1/x week on Mondays and want to switch to 2x/week, simply inject your new, smaller dose next Monday morning and the other half Thursday night. That's all there is to it.

There is no real firm guideline that says this injection schedule will do this and this one will do that. In general, guys inject smaller doses more frequently in order to minimize spikes and reduce side effects like high E2 and HCT. In general, more frequent schedules will reduce spikes, but in terms of reducing side effects, people have mixed results. The only way to know is to try and see what it does for you.

And remember when experimenting with protocols that you need to give it 6+ weeks before you make any other changes.

In terms of how injection frequency may change your libido - that is entirely individual and you just have to try and see. It might not make any difference, it might be just what you need.

You asked about venous leakage - IMHO low dose daily Cialis should be an important part of your protocol. The nocturnal erections that might come along with a balanced TRT protocol combined with the improved blood flow from Cialis could be what you need to allow some healing to occur. Good luck.

 

[DDD]

Thank you very much. I posted three times partly because I wasn't sure if I posted in the right place, or maybe wasn't clear with the title.

Quick question-- Why wouldn't I want to start the smaller twice weekly injections on Thursdays after my last Monday weekly injection, when my T would be higher? I'm usually around 1000 by Thursdays. If I wait until the next Monday, I'm usually 500-700.

The reason I would want to go to twice weekly or E3D is for these reasons--- less swing in my T and E2 numbers from beginning to end of 7 day cycle, to possibly lessen or discontinue anastrozole, and to have a more consistent libido.

 

[DDD]

Also on weekly injections my highest level is 1200-1300 1-2 days after injection. Then 7 days later right before I take my next injection my level is 500-600. Is that too much of a swing? Sometimes I think I feel the difference between the beginning of the cycle when I'm 1200-1300 and then end of the cycle when I'm 500-600. Is it possible to feel the differnence between when my T is 1200 and when it's 600?

 

[RLW]

How exactly is a venous leak diagnosed? I ask because I have no idea and I suspect that unless it is diagnosed with some sort of imaging or study vs just your doctor telling you that's your problem that it might not be the case.

If you are taking 150mg of T cypionate on Monday and your E2 after not taking an AI is 53 on Tuesday then why not split it into twice a week and try to drop the AI?

 

[SilverSurfer]

Also on weekly injections my highest level is 1200-1300 1-2 days after injection. Then 7 days later right before I take my next injection my level is 500-600. Is that too much of a swing? Sometimes I think I feel the difference between the beginning of the cycle when I'm 1200-1300 and then end of the cycle when I'm 500-600. Is it possible to feel the differnence between when my T is 1200 and when it's 600?

What is your SHBG?

 

[Vince Carter]

Also on weekly injections my highest level is 1200-1300 1-2 days after injection. Then 7 days later right before I take my next injection my level is 500-600. Is that too much of a swing? Sometimes I think I feel the difference between the beginning of the cycle when I'm 1200-1300 and then end of the cycle when I'm 500-600. Is it possible to feel the differnence between when my T is 1200 and when it's 600?

Simple observation that I've been reading and was questioned above...you're making so many posts on the same thing, and starting threads, that I don't think I could offer you any thing really worthwhile until you get more focused and much less of this shotgun spread pattern that you're working with right now. Almost seems a little manic too me.

 

[Vince Carter]

I knew it wasn't just me seeing it

FYI you now have 3 consecutive posts all asking more or less the same questions.

 

[DDD]

Simple observation that I've been reading and was questioned above...you're making so many posts on the same thing, and starting threads, that I don't think I could offer you any thing really worthwhile until you get more focused and much less of this shotgun spread pattern that you're working with right now. Almost seems a little manic too me.

I'm not sure what you mean when you say shotgun pattern. My purpose was to ask a few questions and see what those who are experienced on TRT have to say. I posted a few times because I wasn't sure I posted in the right place and am still learning to manuever this site. My questions are meant to be honest questions, I assure you.

 

[DDD]

How exactly is a venous leak diagnosed? I ask because I have no idea and I suspect that unless it is diagnosed with some sort of imaging or study vs just your doctor telling you that's your problem that it might not be the case.

If you are taking 150mg of T cypionate on Monday and your E2 after not taking an AI is 53 on Tuesday then why not split it into twice a week and try to drop the AI?

That's why I am thinking of going to twice weekly. I was on twice weekly before without any AI and my E2 would still be high 30s, low 40s, so I would take .1mg anastrozole after each injection.

 

[RLW]

That's why I am thinking of going to twice weekly. I was on twice weekly before without any AI and my E2 would still be high 30s, low 40s, so I would take .1mg anastrozole after each injection.

Were you having symptoms with your E2 in the high 30's and low 40's? A lot of guys have no issues at those levels.

 

[DDD]

Were you having symptoms with your E2 in the high 30's and low 40's? A lot of guys have no issues at those levels.

I thought that I noticed it was harder to get erections when my E2 started to creep into the high 30s and 40s. But it has been difficult to judge what acceptable E2 levels are for me because the venus leak interferes. It may be the main culprit is the venus leak and maybe the E levels of high 30s or 40s may not have been the main issue.